中国免疫学杂志2025，Vol.41Issue(3)：680-685,6.DOI:10.3969/j.issn.1000-484X.2025.03.029
51例苏州地区多发性硬化患者的临床特征及预后影响因素分析
Analysis of clinical characteristics and prognostic factors of 51 patients with multiple sclerosis in Suzhou area
乔本玉 1曹勇军 2张艳林 2吴小珂 2宋文丽 2李科儒 2李后德 2蒋雨 2张金茹 2徐晓东 2陈冬勤2
作者信息
- 1. 苏州大学附属第二医院神经内科,苏州 215000||连云港市中医院神经内科,连云港 222004
- 2. 苏州大学附属第二医院神经内科,苏州 215000
- 折叠
摘要
Abstract
Objective:To explore clinical characteristics of multiple sclerosis(MS)patients in Suzhou,and to analyze main factors affecting their prognosis.Methods:General data,clinical symptoms,cerebrospinal fluid and imaging examinations of 51 MS patients admitted to Department of Neurology of the Second Hospital of Soochow University from July 31,2009 to July 31,2021 were retrospectively analyzed,and main factors affecting their prognosis were discussed.Results:Average age of onset of 51 MS patients was(43.3±15.6)years old,female accounted for 56.9%,male/female=1/1.3.Adult onset MS(AOMS)accounted for 62.8%,male/female=1/1.7;late onset MS(LOMS)accounted for 37.2%,male/female=1/0.9.Relapsing remitting MS(RRMS)accounted for 76.5%,and chronic onset accounted for 60.8%.Average annual recurrence rate was 8.8%.The first symptoms were numbness and weakness of limbs.Dizziness and numbness were more common in patients without recurrence after diagnosis of MS,and limb weak-ness and numbness were more common in patients with recurrence.Among lesions of MRI,62.7%(32/51)of periventricular involve-ment,52.9%(27/51)of spinal cord involvement,51.0%(26/51)of infratentorial involvement.Proportion of subtentorial and spinal cord(cervical,thoracic)involved were significantly higher in patients with recurrent MS than without recurrence.Values of albumin,IgG,IgA and IgM in cerebrospinal fluid increased with increase of recurrence times.EDSS score of male was higher than female,and LOMS score was higher than AOMS.MS patients without relapse had a low EDSS score,and median EDSS score at current follow-up was 0(0,1.00)score.MS score with relapse was relatively high,and median EDSS score at current follow-up was 2.75(0.25,7.25)score.Conclusion:MS patients with chronic onset are more common,with a high proportion of LOMS,and proportion of males increases with increasing age of onset.High EDSS score at first onset,cervical,thoracic and subtentorial lesions,increased values of cerebrospinal fluid albumin,IgG,IgA,IgM,age at first onset(50+years old),male associate with poor MS prognosis.关键词
多发性硬化/预后/晚发/临床特征Key words
Multiple sclerosis/Prognosis/Late onset/Clinical characteristics分类
医药卫生引用本文复制引用
乔本玉,曹勇军,张艳林,吴小珂,宋文丽,李科儒,李后德,蒋雨,张金茹,徐晓东,陈冬勤..51例苏州地区多发性硬化患者的临床特征及预后影响因素分析[J].中国免疫学杂志,2025,41(3):680-685,6.
