中国免疫学杂志2025，Vol.41Issue(3)：698-703,6.DOI:10.3969/j.issn.1000-484X.2025.03.033
免疫应答与自身免疫病的昼夜节律研究进展
Research progress on circadian rhythm of immune response and autoimmune diseases
摘要
Abstract
The immune system is the cornerstone of the human body to resist danger and maintain homeostasis.The dysfunc-tion of the immune system leads to autoimmune diseases,tumors and other immune-related diseases.The mechanisms of the activation and regulation of the immune system is the frontier research field of life science and medicine.Circadian rhythms control individual ac-tivities and behaviors at various levels such as cells,tissues,organs,and play a key regulatory role in the immune system.Innate im-munity and adaptive immunity are strictly regulated by the biological clock,and the clock control genes in immune cells have diversi-fied effects on cell migration,development,functional differentiation and activation.This article summarizes the circadian regulation of innate and adaptive immunity,and discusses the association and potential intervention value of the biological clock with immune-re-lated diseases as a representative of autoimmune diseases.关键词
昼夜节律/免疫系统/生物钟/自身免疫病Key words
Circadian rhythm/Immune system/Biological clock/Autoimmune diseases分类
医药卫生引用本文复制引用
费彦亢,孙更,刘娟..免疫应答与自身免疫病的昼夜节律研究进展[J].中国免疫学杂志,2025,41(3):698-703,6.基金项目
国家重点研发计划(2023YFA1801400) （2023YFA1801400）
国家自然科学基金(92374115). （92374115）
