中国免疫学杂志2025，Vol.41Issue(3)：704-708,5.DOI:10.3969/j.issn.1000-484X.2025.03.034
S100a8、S100a9在支气管哮喘发生机制中的研究进展
Research progress of S100a8 and S100a9 in pathogenesis of bronchial asthma
摘要
Abstract
S100a8 and S100a9 protein are important members of the S100 protein family.It can induce inflammation by acti-vating intracellular signal cascade,and its strong calcium binding ability makes it play an important role in regulating cell contraction.It has been reported that S100a8 and S100a9 could not only regulate asthmatic airway inflammation,but also have a protective effect on asthmatic airway hyperresponsiveness.This article intends to review the role of S100a8 and S100a9 proteins in airway inflammation and airway hyperresponsiveness in asthma,so as to provide new ideas for the research and prevention of asthma.关键词
S100a8/S100a9/哮喘/AHRKey words
S100a8/S100a9/Asthma/AHR分类
医药卫生引用本文复制引用
袁小慧,陈莉延..S100a8、S100a9在支气管哮喘发生机制中的研究进展[J].中国免疫学杂志,2025,41(3):704-708,5.基金项目
重大慢性非传染性疾病防控研究重点专项(2018YFC1311403) （2018YFC1311403）
国家自然科学基金面上项目(81470221) （81470221）
广东省自然科学基金(2017A030313811) （2017A030313811）
广东省教育厅研究生教育创新计划项目(2017JGXM-MS48) （2017JGXM-MS48）
呼吸疾病国家重点实验室自主课题(青年项目)(SKLRD-QN-201701). （青年项目）
