中国免疫学杂志2025，Vol.41Issue(3)：709-713,5.DOI:10.3969/j.issn.1000-484X.2025.03.035
糖代谢重编程调控炎症反应的研究进展
Research progress on regulation of inflammatory response by glucose metabolic reprogramming
摘要
Abstract
Inflammatory response is a common feature of many acute and chronic diseases,which involves in activation of various cell types.Similar to tumor cells,inflammatory response is regulated by glucose metabolic reprogramming.Cells involved in pro-inflammatory response,such as M1 macrophages,Th1 and Th17 lymphocytes,must generate energy rapidly through glycolysis transformed by glucose metabolic reprogramming to promote inflammation,while cells involved in immune regulation and anti-inflam-matory response,such as regulatory T cells and M2 macrophages,preferentially use fatty acid oxidation and oxidative phosphorylation as a main source for energy production.This article systematically reviews the role of glucose metabolic reprogramming in different stages of inflammatory response,as well as the various molecular mechanisms of glucose metabolic reprogramming in inflammatory response,including activation or inhibition of signaling pathways,epigenetic regulation,post-transcriptional regulation and post-translational modification,which aims to provide a reference for exploring the specific regulatory mechanisms of glucose metabolic reprogramming on inflammatory response and the therapeutic targets of inflammatory-related diseases.关键词
糖代谢重编程/炎症反应/代谢中间产物/表观遗传调控/转录后调控/翻译后修饰Key words
Glucose metabolic reprogramming/Inflammatory response/Metabolic intermediates/Epigenetic regulation/Post-transcriptional regulation/Post-translational modification分类
医药卫生引用本文复制引用
付庭吕,熊锐,李宁,耿庆..糖代谢重编程调控炎症反应的研究进展[J].中国免疫学杂志,2025,41(3):709-713,5.基金项目
国家自然科学基金(81770095,82102269) （81770095,82102269）
中央高校基本科研专项基金(2042021kf0081) （2042021kf0081）
湖北省自然科学基金创新群体项目(2020CFA027). （2020CFA027）
