中国免疫学杂志2025，Vol.41Issue(3)：714-720,7.DOI:10.3969/j.issn.1000-484X.2025.03.036
氧感知信号通路在类风湿关节炎中的研究进展
Research advances of oxygen-sensing signaling pathway in rheumatoid arthritis pathogenesis
摘要
Abstract
Rheumatoid arthritis(RA)is an autoimmune disease characterized by synovitis,synovial cell proliferation,neo-vascularization,and bone and cartilage destruction.Its pathogenesis is complex and has not yet been fully elucidated.A variety of cells,cytokines and signaling pathways are involved in the pathogenesis of RA.Hypoxia-inducing factor(HIF)and oxygen-sensing signaling pathway(PHD-HIF-VHL)are closely related to the occurrence and development of RA,and play an important role in syno-vial cell proliferation,inflammatory response and cartilage destruction.In this study,the research progress of oxygen sensing signaling pathway in RA was described from the aspects of the mechanism of oxygen sensing signaling pathway and its involvement in the patho-genesis of RA,in order to provide ideas and theoretical basis for the research of anti-RA drugs by targeting important molecules of oxy-gen sensing signaling pathway.关键词
氧感知/类风湿关节炎/缺氧诱导因子/信号通路/血管生成Key words
Oxygen sense/Rheumatoid arthritis/Hypoxia inducible factor/Signal pathway/Angiogenes分类
医药卫生引用本文复制引用
刘小曼,沈小兰,郭响,张婧恺,侯晓强,冯知涛..氧感知信号通路在类风湿关节炎中的研究进展[J].中国免疫学杂志,2025,41(3):714-720,7.基金项目
国家自然科学基金项目(82274333) （82274333）
广东省省级科技计划项目(2016A020226001). （2016A020226001）
