中国肺癌杂志2025，Vol.28Issue(3)：201-212,12.DOI:10.3779/j.issn.1009-3419.2025.106.06
中性粒细胞胞外诱捕网在肺癌中的研究进展
Research Progress of Neutrophil Extracellular Traps in Lung Cancer
摘要
Abstract
Neutrophil extracellular traps(NETs),intricate reticular structures released by activated neutrophils,play a pivotal regulatory role in the pathogenesis of malignant tumors.Lung cancer is one of the most prevalent malignancies globally,with persistently high incidence and mortality rates.Recent studies have revealed that NETs dynamically modulate the tumor microenvironment through unique pathological mechanisms,exhibiting complex immunoregulatory characteristics during the progression of lung cancer,and this discovery has increasingly become a focal point in tumor immunology research.This paper provides a comprehensive review of the latest advancements in NETs research related to lung cancer,offering an in-depth analysis of their impact on lung cancer progression,their potential diagnostic value,and the current state of research on targeting NETs for lung cancer prevention and treatment.The aim is to propose novel strategies to enhance therapeutic out-comes and improve the prognosis for lung cancer patients.关键词
肿瘤相关中性粒细胞/中性粒细胞胞外诱捕网/肺肿瘤/肿瘤微环境Key words
Tumor associated neutrophils/Neutrophil extracellular traps/Lung neoplasms/Tumor microenviron-ment引用本文复制引用
郝旭,杨慧彤,冯祎琳,禄安琪,孙颖,夏金婵,梅雪,冯龙,蒋敏,王白燕..中性粒细胞胞外诱捕网在肺癌中的研究进展[J].中国肺癌杂志,2025,28(3):201-212,12.基金项目
This paper was supported by the grants from Henan Provincial Science and Technology R&D Program Joint Fund(Advantageous Discipline Cultivation)Project(No.242301420105)and Programs for Science and Technology Development of Henan Province(No.232102311111)(Both to Ying SUN). 本文受河南省科技研发计划联合基金(优势学科培育类)项目(No.242301420105)和河南省科技攻关项目(No.232102311111)资助 （Advantageous Discipline Cultivation）
