中国免疫学杂志2025，Vol.41Issue(3)：721-726,6.DOI:10.3969/j.issn.1000-484X.2025.03.037
m6A修饰参与调控天然免疫的研究进展
Progress of m6A modification involved in regulation of innate immunity
摘要
Abstract
N6-methyladenosine(m6A)modification is considered to be the most common eukaryotic RNA modification.Under regulation of writers,erasers and readers,m6A mediates RNA transcription,nuclear export,splicing,translation and other processes.Innate immunity is body's first line of defense against pathogen invasion,and under stimulation of pathogens and foreign bodies,it rapidly produces non-specific protective response.Recent studies have found that m6A modification plays an important role in process of innate immunity,participating in regulation of innate immunity by targeting innate immune cells,affecting immune recognition,and regulating antiviral responses.This article reviews molecular mechanism of m6A modification and its progress in innate immunity,providing new ideas for treatment strategies of related diseases based on m6A modification.关键词
N6-甲基腺苷/天然免疫/病毒/巨噬细胞Key words
N6-methyladenosine/Innate immunity/Virus/Macrophages分类
医药卫生引用本文复制引用
徐宸桢,李宁,王文捷,耿庆..m6A修饰参与调控天然免疫的研究进展[J].中国免疫学杂志,2025,41(3):721-726,6.基金项目
国家自然科学基金面上项目(82102269) （82102269）
中央高校基本科研专项资金(2042021kf0081). （2042021kf0081）
