中国肺癌杂志2025，Vol.28Issue(3)：213-220,8.DOI:10.3779/j.issn.1009-3419.2025.106.08
免疫检查点通过代谢途径介导肿瘤免疫调控
Immune Checkpoints Mediate Tumor Immune Regulation through Metabolic Pathways
摘要
Abstract
Immune checkpoints include a series of receptor-ligand pairs that play a key role in the proliferation,activation,and immune regulatory responses of immune cells.Although immune checkpoint inhibitors(ICIs),such as pro-grammed death protein 1(PD-1)and cytotoxic T-lymphocyte-associated protein 4(CTLA-4)have achieved good therapeu-tic effects in clinical practice,some patients still experience ineffective treatment and immune resistance.A large amount of evidence has shown that immune checkpoint proteins are related to cell metabolism during immune regulation.On the one hand,immune checkpoints connect to alter the metabolic reprogramming of tumor cells to compete for nutrients required by immune cells.On the other hand,immune checkpoints regulate the metabolic pathways of immune cells,such as phosphati-dylinositol 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)to affect the activation of immune cells.Based on a review of the literature,this article reviews the mechanisms by which PD-1,CTLA-4,T cell immunoreceptor with Ig and ITIM domains(TIGIT),T cell immunoglobulin and mucin domain-containing protein 3(TIM-3),cluster of dif-ferentiation 47(CD47),and indoleamine 2,3-dioxygenase 1(IDO1)regulate cell metabolic reprogramming,and looks forward to whether targeting the ligand-receptor pairs of immune checkpoints in a"dual regulation"manner and inhibiting metabolic pathways can effectively solve the problem of tumor immune resistance.关键词
免疫检查点/肿瘤微环境/免疫代谢/肿瘤免疫Key words
Immune checkpoints/Tumor microenvironment/Immune metabolism/Tumor immune引用本文复制引用
杜伟光,唐希阳,周玉龙,李梦超,金泽,窦家琪,赵晋波..免疫检查点通过代谢途径介导肿瘤免疫调控[J].中国肺癌杂志,2025,28(3):213-220,8.基金项目
This paper was supported by the grant of Shanxi Provincial Outstanding Youth Science Fund Project(No.S2024-JC-JQ-0387)(to Jinbo ZHAO). 本文受陕西省杰出青年科学基金项目(No.S2024-JC-JQ-0387)资助 （No.S2024-JC-JQ-0387）
