中国肺癌杂志2025，Vol.28Issue(3)：221-229,9.DOI:10.3779/j.issn.1009-3419.2025.102.08
靶向YAP/TAZ信号通路改善肿瘤免疫治疗的研究进展
Research Advances in Targeting the YAP/TAZ Signaling Pathway to Improve Cancer Immunotherapy
摘要
Abstract
Despite the groundbreaking advances in cancer immunotherapy achieved by immune checkpoint inhibi-tors(ICIs),their efficacy remains limited by the immunosuppressive tumor microenvironment(TME).Yes-associated protein(YAP)and transcriptional coactivator with PDZ-binding motif(TAZ),key effectors of the Hippo signaling pathway,play piv-otal roles in tumor immune evasion.They directly regulate the expression of immune checkpoints,mediate the formation of an immunosuppressive microenvironment,inhibit T cell function,and interact with other signaling pathways to promote immune escape.Diverse strategies targeting YAP/TAZ have been developed,including direct inhibition,modulation of upstream regu-lators,and suppression of downstream target genes.Preclinical studies have demonstrated that combining YAP/TAZ inhibition with ICIs significantly enhances therapeutic efficacy across various tumor models.This review summarizes recent advances in understanding the role of YAP/TAZ in immune evasion within the TME and explores the potential of targeting this pathway to improve immunotherapy outcomes.Furthermore,it discusses the translational value of combination therapies based on YAP/TAZ inhibition,providing a theoretical framework and practical guidance for the development of innovative immunotherapeu-tic strategies and precision medicine approaches.关键词
YAP/TAZ/免疫治疗/免疫逃逸/肿瘤微环境Key words
YAP/TAZ/Immunotherapy/Immune evasion/Tumor microenvironment引用本文复制引用
张平旭,展翼翼..靶向YAP/TAZ信号通路改善肿瘤免疫治疗的研究进展[J].中国肺癌杂志,2025,28(3):221-229,9.基金项目
This paper was supported by the grant from the"Tianshan Elite"High-Level Talent Cultivation Program for Medicine and Health(No.TSYC202301B071)(to Yiyi ZHAN). 本文受"天山英才"医药卫生高层次人才培养计划项目(No.TSYC202301B071)资助 （No.TSYC202301B071）
