中国肺癌杂志2025，Vol.28Issue(3)：230-236,7.DOI:10.3779/j.issn.1009-3419.2025.102.10
EML4-ALK融合基因阳性肺多原发神经内分泌癌1例
A Case of Multiple Primary Pulmonary Neuroendocrine Carcinoma with EML4-ALK Fusion Gene Positive
摘要
Abstract
Neuroendocrine carcinoma(NEC),a subtype of neuroendocrine tumors with high proliferative activity,is characterized by strong invasiveness and poor prognosis.This article reports a previously healthy female non-smoker who de-veloped NEC occurring sequentially in different lobes of both lungs.The lesions were pathologically diagnosed by hematoxylin-eosin(HE)staining as large cell neuroendocrine carcinoma(LCNEC)and small cell lung cancer(SCLC),respectively.Next-generation sequencing(NGS)performed on both lesions revealed the presence of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase(EML4-ALK)fusion mutations in both lesions.Notably,the patient achieved a significant therapeutic response to ALK-tyrosine kinase inhibitors(TKIs)targeted therapy.关键词
肺肿瘤/肺大细胞神经内分泌癌/ALK突变/靶向治疗Key words
Lung neoplasms/Large cell neuroendocrine carcinoma of the lung/ALK mutation/Targeted therapy引用本文复制引用
张尹,侯悦,张天明,王虹..EML4-ALK融合基因阳性肺多原发神经内分泌癌1例[J].中国肺癌杂志,2025,28(3):230-236,7.基金项目
This paper was supported by the grants from Nature Science Foundation of Gansu Province(No.24JRRA371)(to Hong WANG),Nature Science Foundation of Gansu Province(No.25JRRA607)(to TianMing ZHANG)and Cuiying Science and Technology Innovation Program of Lanzhou University Second Hospital(No.CY2024-LC-B03)(to Hong WANG). 本文受甘肃省自然科学基金项目(No.24JRRA371)、甘肃省自然科学基金项目(No.25JRRA607)和兰州大学第二医院萃英科技创新计划项目(No.CY2024-LC-B03)资助 （No.24JRRA371）
