中国免疫学杂志2025，Vol.41Issue(3)：733-739,7.DOI:10.3969/j.issn.1000-484X.2025.03.039
枯否细胞亚群与功能的研究进展
Research progress of Kupffer cell subsets and their functions
摘要
Abstract
Kupffer cells(KC),the hepatic resident macrophages,are located in the sinusoids,and play a crucial role in clearing intestinal-derived pathogens and damaged red blood cells,regulating iron and fat metabolism,and maintaining immune toler-ance.In acute and chronic hepatopathy,KC are implicated in liver injury and repair by crosstalk between other hepatocellular popula-tions such as hepatocytes,endothelial cells,hepatic stellate cells and so on,by which maintain liver homeostasis.KC are highly plas-tic,and different liver disease models and different hepatic microenvironmental signals can induce changes in the phenotype and func-tion of hepatic macrophages.In this review,we summarize the subsets of KC and their functions in specific liver disease models based on cell origin,cell polarization,cell surface markers,and gene expression profiles identified by single-cell sequencing techniques.We are aiming to target specific KC subsets to prevent or treat related liver diseases,and promote the progress of precision medicine for liver diseases.关键词
枯否细胞/细胞极化/细胞表面标志物/单细胞RNA测序Key words
Kupffer cells/Cell polarization/Cell surface markers/Single-cell RNA sequencing分类
医药卫生引用本文复制引用
赵赛,于倩,刘亮明..枯否细胞亚群与功能的研究进展[J].中国免疫学杂志,2025,41(3):733-739,7.基金项目
国家自然科学基金项目(81770612). （81770612）
