中国实用口腔科杂志2025，Vol.18Issue(2)：222-225,231,5.DOI:10.19538/j.kq.2025.02.015
D-氨基酸在口腔细菌生物膜中作用研究进展
Research progress in the role of D-amino acids in oral bacterial biofilms
摘要
Abstract
Biofilms are ubiquitous in nature and are related to many chronic infectious diseases.Dental plaque biofilm is a complex multi-species structure composed of aerobic and anaerobic micro-organisms,and is the initiator of dental car-ies,refractory chronic periapical periodontitis,periodontal disease and peri-implantitis.Bacteria in biofilms have unique gene expression and metabolic activities,which make it difficult for antibiotics to exert their antibacterial effects and make it possible to evade the host immune system.In recent years,the inhibitory effect of D-amino acids on biofilm for-mation and the dispersion effect on mature biofilms have been widely studied.The article reviews the research progress in the role of D-amino acids in oral bacterial biofilms,in order to provide new ideas for the development of new therapeu-tic drugs for dental plaque biofilms.关键词
D-氨基酸/生物膜/变异链球菌/粪肠球菌/牙龈卟啉单胞菌Key words
D-amino acids/biofilm/Streptococcus mutans/Enterococcus faecalis/Porphyromonas gingivalis分类
医药卫生引用本文复制引用
任玲,郑博文,刘奕..D-氨基酸在口腔细菌生物膜中作用研究进展[J].中国实用口腔科杂志,2025,18(2):222-225,231,5.基金项目
沈阳市中青年科技创新人才支持计划(RC210001) （RC210001）
