中国免疫学杂志2025，Vol.41Issue(3)：740-742,750,4.DOI:10.3969/j.issn.1000-484X.2025.03.040
间充质干细胞的免疫调节作用及其在免疫性血小板减少症中的研究进展
Mesenchymal stem cells:Immunodulatory effects and advances in immune thrombocytopenia
摘要
Abstract
Pathogenesis of immune thrombocytopenia(ITP)is complex,with a high reoccurence rate after first-line treatment and limited efficacy of second-line treatment,especially in refractory ITP,for which there is a lack of effective treatment.In recent years,it has been found that impaired function of mesenchymal stem cells(MSCs)is also involved in pathogenesis of ITP in addition to humoral and cellular immunity.Exogenous infusion of MSCs or endogenous restoration of immunomodulatory function of MSCs is expected to be an effective treatment strategy for ITP.Therefore,this article reviews biological characteristics and immunomodulatory effects of MSCs and their research progress in ITP,with aim of providing new ideas for further elucidating pathogenesis and exploring effective treatment options of ITP.关键词
免疫性血小板减少症/间充质干细胞/免疫调节/免疫治疗Key words
Immune thrombocytopenia/Mesenchymal stem cells/Immune regulation/Immunotherapy分类
医药卫生引用本文复制引用
唐川惠,文瑞婷,杨志刚..间充质干细胞的免疫调节作用及其在免疫性血小板减少症中的研究进展[J].中国免疫学杂志,2025,41(3):740-742,750,4.基金项目
国家自然科学基金(82200238) （82200238）
广东省自然科学基金(2021A1515010708) （2021A1515010708）
湛江市财政资金科技专项竞争性分配项目(2021A05153,2021A05150). （2021A05153,2021A05150）
