中国免疫学杂志2025，Vol.41Issue(3)：743-750,8.DOI:10.3969/j.issn.1000-484X.2025.03.041
单细胞测序分析BCR CDR3受体库的研究概况和进展
Research overview and progress of single-cell sequencing analysis of BCR CDR3 receptor repertoire
摘要
Abstract
B cell receptor(BCR)is the main molecular basis for B cell specific recognition and binding of antigen,and its complementarity determining region(CDR3)presents high diversity and specificity.Using single-cell immune repertoire sequencing technology can accurately analyze the composition and characteristics of each B cell BCR CDR3 sequence,and can better understand the process and mechanism of B cell differentiation,development,and response.Single-cell immune repertoire sequencing technology provides new ideas and theoretical basis for the pathogenesis,monitoring,diagnosis and treatment of B-cell immune-related diseases.This paper mainly compares and analyzes the commonly used detection methods and detection platforms of B-cell BCR CDR3 receptor library,and focuses on the application,research status and progress of single-cell sequencing technology in B-cell BCR CDR3 recep-tor library.关键词
B细胞受体/CDR3受体库/单细胞测序Key words
B cell receptor/CDR3 receptor library/Single-cell sequencing分类
医药卫生引用本文复制引用
朱兰伟,李俊,马龙,姚新生..单细胞测序分析BCR CDR3受体库的研究概况和进展[J].中国免疫学杂志,2025,41(3):743-750,8.基金项目
国家自然科学基金(81860300) （81860300）
贵州省高层次创新人才项目([2018]5637). （[2018]5637）
