中国全科医学2025，Vol.28Issue(17)：2142-2148,7.DOI:10.12114/j.issn.1007-9572.2024.0313
细胞周期蛋白D1和细胞周期蛋白E1基因多态性及其交互作用与先兆子痫的关联研究
Study on the Association between Polymorphisms and Interaction of CCND1 and CCNE1 Genes with Preeclampsia
摘要
Abstract
Background Preeclampsia(PE)is a life-threatening multisystemic disorder that significantly endangers maternal and fetal health.Objective To investigate the association between CCND1(Cyclin D1)and CCNE1(Cyclin E1)gene polymorphisms,as well as their interactions with the risk of PE,and provide scientific evidence for its pathogenesis.Methods A case-control study was conducted.From October 2020 to October 2023,pregnant women diagnosed with PE were recruited from the Xiangya Third Hospital of Central South University and the Hunan Provincial Maternal and Child Health Hospital as the case group(n=202),while pregnant women with normal blood pressure were recruited as the control group(n=400).Multivariate Logistic regression analyses were performed to evaluate the association between CCND1 and CCNE1 gene polymorphisms and the risk of PE,with adjusted odds ratios(aOR)and 95%confidence intervals(95%CI)calculated.Interaction analysis was performed to investigate the association between gene-gene interactions and PE risk.Functional annotation of single nucleotide polymorphisms(SNP)was performed using the 3DSNP database.Results Multivariate Logistic regression analysis revealed that pregnant women with the CT/TT genotype at CCND1 rs1352075 had a lower risk of PE compared to CC genotype(dominant model:aOR=0.44,95%CI=0.20-0.96).Pregnant women with the GG genotype at CCNE1 rs3218070 had a higher risk of PE compared to CC/GC genotype(recessive model:aOR=4.31,95%CI=1.16-16.04).Analysis based on the 3DSNP database revealed a higher proportion of cellular regulatory factors related to vascularization and placentation in the open chromatin regions at rs1352075 and rs3218070 binding sites.Interaction analysis showed that the additive interaction between rs1352075 and rs3218070 was not significantly associated with PE risk.Conclusion The CCND1 rs1352075 locus harboring the CC genotype and the CCNE1 rs3218070 locus harboring the GG genotype may be associated with an elevated risk of developing PE.关键词
先兆子痫/细胞周期蛋白D1/细胞周期蛋白E1/单核苷酸基因多态性/病例对照研究/Logistic回归分析Key words
Pre-eclampsia/Cyclin D1/Cyclin E1/Single nucleotide polymorphism/Case-control study/Logistic regression analysis分类
医药卫生引用本文复制引用
周韵哲,苗竣翔,韦杰桦,陈立章,王婷婷..细胞周期蛋白D1和细胞周期蛋白E1基因多态性及其交互作用与先兆子痫的关联研究[J].中国全科医学,2025,28(17):2142-2148,7.基金项目
国家自然科学基金资助项目(82173608) （82173608）
