中国药业2025，Vol.34Issue(7)：101-104,4.DOI:10.3969/j.issn.1006-4931.2025.07.022
生肌玉红膏联合柑橘黄酮片对混合痔术后患者肛门功能、创面恢复及创面组织的影响
Effect of Shengji Yuhong Cream Combined with Citrus Flavonoid Tablets on Anal Function,Wound Healing,and Wound Tissue in Postoperative Patients with Mixed Hemorrhoids
摘要
Abstract
Objective To investigate the effect of Shengji Yuhong Cream combined with Citrus Flavonoid Tablets on anal function,wound healing,and the levels of wound tissue such as fibronectin(FN),vascular endothelial growth factor(VEGF),CXC chemokine receptor 4(CXCR4),and type Ⅰ collagen(COL-Ⅰ)in postoperative patients with mixed hemorrhoids.Methods A total of 160 patients with mixed hemorrhoids admitted to the hospital from January 2022 to December 2023 were selected and divided into the test group and the control group by the random number table method,with 80 cases in each group.One case in each group was excluded due to poor treatment compliance or voluntary withdrawal,resulting in 79 cases in each group.The patients in the two groups underwent external excision and internal ligation for mixed hemorrhoids,and received routine treatments such as intravenous infusion of antibiotics and bath solution after surgery.The patients in the control group were treated with conventional Vaseline gauze strips and oral Citrus Flavonoids Tablets after surgery,while the patients in the test group were treated with Shengji Yuhong Cream gauze strips and oral Citrus Flavonoid Tablets after surgery.Both groups were treated until the wound healed.Results The disappearance time of exudate,the time for granulation tissue to level with the wound,and the time for wound healing in the test group were significantly shorter than those in the control group(P<0.05).After treatment,the maximum rectal volume threshold,anal resting pressure,and rectal sensory threshold in the two groups were significantly lower than those before treatment(P<0.05),but those in the test group were significantly higher than those in the control group(P<0.05);there was no significant difference in anal systolic pressure compared with those before treatment(P>0.05);the anal pain and edema scores in the two groups were significantly lower than those before treatment(P<0.05),and those in the test group were significantly lower than those in the control group(P<0.05);the expression levels of VEGF,FN,and COL-Ⅰ in the wound tissues in the two groups were significantly higher than those before treatment(P<0.05),while the expression level of CXCR4 in the two groups was significantly lower than those before treatment(P<0.05),and those in the test group were significantly better than those in the control group(P<0.05).The incidence of complications in the test group was 3.80%,which was significantly lower than 12.66%in the control group(P<0.05).Conclusion Shengji Yuhong Cream combined with Citrus Flavonoid Tablets in the treatment of mixed hemorrhoids can promote postoperative neovascularization,wound healing,and anal function recovery,and reduce complications.关键词
生肌玉红膏/柑橘黄酮片/混合痔/新生血管形成/创面愈合/肛门功能Key words
Shengji Yuhong Cream/Citrus Flavonoid Tablets/mixed hemorrhoids/angiogenesis/wound healing/anal function分类
药学引用本文复制引用
杨周雨,钟培,李可,陈劲松,李心茹..生肌玉红膏联合柑橘黄酮片对混合痔术后患者肛门功能、创面恢复及创面组织的影响[J].中国药业,2025,34(7):101-104,4.基金项目
湖南省中医药管理局中医药科研课题[B2023105]. （）
