中国药业2025，Vol.34Issue(7)：109-112,4.DOI:10.3969/j.issn.1006-4931.2025.07.024
自拟柴黄利胆方联合消炎利胆胶囊治疗慢性胆囊炎临床研究
Clinical Study of Self-Made Chaihuang Lidan Decoction Combined with Xiaoyan Lidan Capsules in the Treatment of Chronic Cholecystitis
摘要
Abstract
Objective To investigate the clinical efficacy of self-made Chaihuang Lidan Decoction combined with Xiaoyan Lidan Capsules in the treatment of chronic cholecystitis,and its effect on gallbladder artery hemodynamics.Methods A total of 106 patients with chronic cholecystitis(live-gallbladder dampeness-heat type)admitted to the hospital from September 2021 to September 2023 were selected and randomly divided into the control group and the observation group by the random number table method,with 53 cases in each group.The patients in the control group received Xiaoyan Lidan Capsules,while the patients in the observation group additionally received self-made Chaihuang Lidan Decoction.Both groups were treated for three courses with 30 d as a course.Results The total effective rate in the observation group was 90.57%,which was significantly higher than 75.47%in the control group(P<0.05).After treatment,the gallbladder artery peak systolic velocity(PSV),end-diastolic velocity(EDV),traditional Chinese medicine(TCM)syndrome scores(hypochondriac pain,abdominal distension and pain,bitter taste and dry mouth,red tongue with yellow coating),hepatobiliary biochemical indexes[total bile acid,total bilirubin,aspartate aminotransferase(AST),alanine aminotransferase(ALT)],and inflammatory factors[transforming growth factor-β1(TGF-β1),B-cell activating factor receptor(BAFF-R),monocyte chemoattractant protein-4(MCP-4)]in the two groups were significantly lower than those before treatment(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05);the pulsatility index(PI)and resistance index(RI)in the two groups were significantly higher than those before treatment(P<0.05),and those in the observation group were significantly higher than those in the control group(P<0.05).The incidence of adverse reactions was comparable between the observation group and the control group(11.32%vs.7.55%,P>0.05).Conclusion Self-made Chaihuang Lidan Decoction combined with Xiaoyan Lidan Capsules in the treatment of chronic cholecystitis has good clinical efficacy and safety,which can effectively alleviate TCM syndromes,reduce hepatobiliary biochemical indices,improve gallbladder artery hemodynamics,and inhibit inflammatory factor expression.关键词
自拟柴黄利胆方/消炎利胆胶囊/慢性胆囊炎/胆囊动脉/血流动力学/临床疗效Key words
self-made Chaihuang Lidan Decoction/Xiaoyan Lidan Capsules/chronic cholecystitis/gallbladder artery/hemodynamics/clinical efficacy分类
药学引用本文复制引用
杨威涛,曹鹏飞,张志宏,杨娇,杨泽江..自拟柴黄利胆方联合消炎利胆胶囊治疗慢性胆囊炎临床研究[J].中国药业,2025,34(7):109-112,4.基金项目
河北省中医药管理局科研计划项目[2021195]. （）
