中国药业2025，Vol.34Issue(7)：113-117,5.DOI:10.3969/j.issn.1006-4931.2025.07.025
双歧杆菌四联活菌片联合吡美莫司乳膏治疗特应性皮炎临床研究
Clinical Study of Bifidobacterium Quadruplex Viable Tablets Combined with Pyrrolimus Cream in the Treatment of Atopic Dermatitis
摘要
Abstract
Objective To investigate the clinical efficacy of Bifidobacterium Quadruplex Viable Tablets combined with Pimecrolimus Cream in the treatment of atopic dermatitis(AD),and its effect on the skin barrier function and immune function of patients.Methods A total of 123 AD patients admitted to the First People's Hospital of Changshu from October 2020 to October 2022 were selected and randomly divided into the control group(62 cases)and the observation group(61 cases)by the random number table method.During the study,one case was lost to follow-up in the observation group and two cases were lost to follow-up in the control group.Ultimately,60 cases were included in each group.The patients in the two groups were treated with Pimecrolimus Cream,while the patients in the observation group were treated with Bifidobacterium Quadruplex Viable Tablets.Both groups were treated continuously for two months and followed up for one year.Results The total effective rate in the observation group was 96.67%,which was significantly higher than 78.33%in the control group(P<0.05).After treatment,compared with those in the control group,the scores of Eczema Area and Severity Index(EASI)and Dermatology Quality of Life Index(DLQI)(P<0.05)in the observation group were significantly lower,the moisture content and sebum content of the stratum corneum in the observation group were significantly higher(P<0.05),while the transcutaneous water loss(TEWL)in the observation group was significantly lower(P<0.05);the CD4+and CD4+/CD8+in the observation group were significantly higher(P<0.05),while the CD8+in the observation group was significantly lower(P<0.05);the levels of serum interferon-γ,interleukin-4,and interleukin-13 in the observation group were significantly lower(P<0.05);the numbers of Bifidobacterium and Lactobacillus in the observation group were significantly higher(P<0.05),while the numbers of Enterococcus and Escherichia coli in the observation group were significantly lower(P<0.05).The recurrence rate within one year in the observation group was 1.67%,which was significantly lower than 15.00%in the control group(P<0.05).Conclusion Bifidobacterium Quadruplex Viable Tablets combined with Pimecrolimus Cream in the treatment of AD has good clinical efficacy,which can effectively relieve symptoms such as eczema and skin lesions,improve skin barrier function and immune function,correct Th1/Th2 cell imbalance,regulate intestinal microbiota,and reduce recurrence rate.关键词
双歧杆菌四联活菌片/吡美莫司乳膏/特应性皮炎/皮肤屏障功能/免疫功能Key words
Bifidobacterium Quadruplex Viable Tablets/Pimecrolimus Cream/atopic dermatitis/skin barrier function/immune function分类
药学引用本文复制引用
谈星,吴园琴..双歧杆菌四联活菌片联合吡美莫司乳膏治疗特应性皮炎临床研究[J].中国药业,2025,34(7):113-117,5.基金项目
江苏省卫生健康委员会医学科研立项项目[ZD20210044]. （）
