中国医院用药评价与分析2025，Vol.25Issue(3)：294-296,3.DOI:10.14009/j.issn.1672-2124.2025.03.008
新疆地区双相情感障碍患者丙戊酸钠血药浓度的影响因素及效果分析
Influencing Factors of Blood Concentration and Efficacy of Sodium Valproate in Patients with Bipolar Affective Disorder in Xinjiang
摘要
Abstract
OBJECTIVE:To probe into the influencing factors of blood concentration and clinical efficacy of sodium valproate in patients with bipolar affective disorder in Xinjiang,so as to provide references for clinical individualized medication.METHODS:Clinical data of patients with bipolar affective disorder who received sodium valproate in the hospital from Jan.2019 to Jul.2024 were retrospectively collected and analyzed in terms of the effects of age,gender,ethnicity and drug combination on blood concentration,the clinical efficacy were observed.RESULTS:A total of 118 patients were enrolled,the blood concentration of sodium valproate was(46.60±25.85)mg/L,47 cases met the standard,with the compliance rate of 39.83%.The blood concentration of sodium valproate was significantly higher in underage patients than that in adult patients,with statistically significant difference(P<0.05),there was no correlation between patient's gender,ethnicity,drug combination and blood concentration(P>0.05).The scores of Hamilton Depression Scale and the Hamilton Anxiety Scale of the 118 patients were significantly lower after treatment(at the time of discharge)than those before treatment(at the time of admission),with statistically significant differences(P<0.05).CONCLUSIONS:In clinical practice of sodium valproate in the treatment of bipolar affective disorder,it is necessary to monitor the blood concentration of sodium valproate and adjust the dosage in a timely manner to improve clinical efficacy.关键词
新疆/双相情感障碍/丙戊酸钠/血药浓度Key words
Xinjiang/Bipolar affective disorder/Sodium valproate/Blood concentration分类
药学引用本文复制引用
吴宛焰,冯杰,张惠兰,李红健,于鲁海..新疆地区双相情感障碍患者丙戊酸钠血药浓度的影响因素及效果分析[J].中国医院用药评价与分析,2025,25(3):294-296,3.基金项目
新疆维吾尔自治区自然科学基金资助项目(No.2023D01C69) （No.2023D01C69）
