中国医院用药评价与分析2025，Vol.25Issue(3)：297-300,4.DOI:10.14009/j.issn.1672-2124.2025.03.009
疾病修饰治疗用于多发性硬化患者的效果及其早期预测因素分析
Effects of Disease-Modifying Therapy for Patients with Multiple Sclerosis and Analysis on Its Early Predictive Factors
摘要
Abstract
OBJECTIVE:To probe into the effects of disease-modifying therapy(DMT)for patients with multiple sclerosis(MS)and to analyze the early predictive factors for poor response to DMT.METHODS:A total of 81 MS patients received DMT in our hospital from Jan.2019 to Mar.2023 were enrolled.The patients were followed up for 1 year and were divided into good response group and poor response group according to the treatment effects.Clinical data of two groups were compared,and Logistic regression was used to analyze the factors associated with poor response to DMT in MS patients.R language software was used to establish the nomogram model,the calibration curve and ROC curve were drawn to evaluate the internal efficacy of the model in early predicting poor response to DMT.RESULTS:After 1 year of follow-up,29 patients presented with poor DMT response and 52 with good response.Patients in the poor response group had significantly higher Expanded Disability Function Scale(EDSS)score,percentage of MRI brain disease activity and percentage of primary progression than those in the good response group,and the duration of disease was significantly longer than that in the good response group,with statistically significant differences(P<0.05).Logistic regression analysis showed that the high EDSS score(OR=4.484),MRI brain disease activity(OR=5.285)and primary progression(OR=4.440)were independently associated with poor DMT response in MS patients(P<0.05).The early prediction nomogram model established with independent factors for early assessment of DMT treatment effects yielded a C-index of 0.912(95%CI=0.874-0.979),and the calibration curve was closely following the ideal curve.The AUC of the nomogram model in early prediction of poor response to DMT was 0.926,with a sensitivity of 96.55%and a specificity of 84.62%.CONCLUSIONS:There is a considerable possibility of poor response during the application of DMT in MS patients,and the construction of prediction model can early evaluate the effects of DMT in MS patients,a more precise treatment regimen could be formulated for each patient.关键词
多发性硬化/疾病修饰治疗/效果/预测因素Key words
Multiple sclerosis/Disease-modifying therapy/Effect/Predictive factor分类
药学引用本文复制引用
陈琳,陈敏,邢槐杰,周经霞,曾超胜..疾病修饰治疗用于多发性硬化患者的效果及其早期预测因素分析[J].中国医院用药评价与分析,2025,25(3):297-300,4.基金项目
海南省重点研发项目(No.ZDYF2022SHFZ291) （No.ZDYF2022SHFZ291）
