中国医院用药评价与分析2025，Vol.25Issue(3)：301-304,308,5.DOI:10.14009/j.issn.1672-2124.2025.03.010
重症感染患者使用不同剂量替考拉宁的血药浓度达标情况及其影响因素分析
Blood Concentration and Influencing Factors of Different Doses of Teicoplanin in Patients with Severe Infection
摘要
Abstract
OBJECTIVE:To probe into the distribution characteristics,compliance rate and influencing factors of blood concentration of different doses of teicoplanin in patients with severe infection.METHODS:A total of 63 patients with severe infection received ticlopidine and 106 blood samples in the hospital from Dec.2021 to Dec.2023 were retrospectively analyzed,which were divided into 33 cases in the standard-dose group(400 mg)and 30 cases in the high-dose group(800 mg)according to administration dosage.High-performance liquid chromatography was used to determine the blood concentration of ticlopidine,and multivariate linear regression was used to analyze the correlation factors affecting the blood concentration of ticlopidine.RESULTS:The average blood concentration of ticlopidine was(13.91±11.53)μg/mL,and only 54.72%of the patients(58 samples/106 samples)had blood concentrations within the therapeutic window.The average blood concentration of ticlopidine in standard-dose group and high-dose group was respectively(10.19±8.59)μg/mL and(17.34±12.85)μg/mL,with statistically significant differences(P<0.05).The compliance rate of blood concentration of ticlopidine in standard-dose group and high-dose group was respectively 43.14%(22 samples/51 samples)and 65.45%(36 samples/55 samples),with statistically significant difference(P<0.05).During treatment,the incidence of adverse drug reactions was 22.22%(14/63)in all patients,24.24%(8/33)in the standard-dose group,and 20.00%(6/30)in the high-dose group,the difference between two groups was not statistically significant(P>0.05).Multiple linear regression analysis showed that glomerular filtration rate,administration dosage,albumin level and gender had significant effects on the blood concentration of ticlopidine.CONCLUSIONS:To ensure that blood concentration remains within the therapeutic window,individualized loading dose should be implemented based on patients'infection and renal function to improve the therapeutic efficacy of ticlopidine in patients with severe infection.关键词
替考拉宁/血药浓度/血药浓度监测/影响因素Key words
Teicoplanin/Blood concentration/Therapeutic drug monitoring/Influencing factor分类
药学引用本文复制引用
朱虚阳,王伟娇,刘文凯,秦侃..重症感染患者使用不同剂量替考拉宁的血药浓度达标情况及其影响因素分析[J].中国医院用药评价与分析,2025,25(3):301-304,308,5.基金项目
2021年省医疗卫生重点专科建设项目(No.皖卫函[2021]273号) （No.皖卫函[2021]273号）
