中国医院用药评价与分析2025，Vol.25Issue(3)：305-308,4.DOI:10.14009/j.issn.1672-2124.2025.03.011
止痒外阴膏联合重组牛碱性成纤维细胞生长因子对外阴硬化性苔藓患者中医证候和焦虑抑郁的影响
Effects of Zhiyang Waiyin Ointment Combined with Recombinant Bovine Basic Fibroblast Growth Factor on Traditional Chinese Medicine Syndrome,Anxiety and Depression in Patients with Vulvar Lichen Sclerosus
摘要
Abstract
OBJECTIVE:To probe into the effects of Zhiyang Waiyin ointment combined with recombinant bovine basic fibroblast growth factor(bFGF)on traditional Chinese medicine(TCM)syndrome,anxiety and depression in patients with vulvar lichen sclerosus(VLS).METHODS:A total of 92 VLS patients admitted into the hospital from Jul.2022 to Jun.2023 were extracted to be divided into control group(46 cases)and research group(46 cases)via random number table method.Both groups were given conventional drug treatment(mometasone furoate cream),while the control group was treated with bFGF,and the research group was given Zhiyang Waiyin ointment based on the control group.The clinical efficacy,TCM syndrome integral,score of Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS),pain degree[score of visual analogue scale(VAS)],quality of life,score of Summary Form of Health Survey(SF-36),incidences of adverse drug reactions and recurrence rate were compared between two groups.RESULTS:The total effective rate of the research group was 93.48%(43/46),significantly higher than 76.09%(35/46)of the control group,with statistically significant difference(P<0.05).After treatment,the SAS score,SDS score,TCM syndrome integral and VAS score of the research group were significantly lower than those of the control group,the SF-36 score of the research group was significantly higher than that of the control group,with statistically significant differences(P<0.05).The incidence of adverse drug reactions and recent recurrence rate of the research group were respectively 4.35%(2/46)and 6.52%(3/46),significantly lower than 17.39%(8/46)and 21.74%(10/46)of the control group,with statistically significant differences(P<0.05).CONCLUSIONS:Zhiyang Waiyin ointment combined with bFGF for the intervention of VLS patients can effectively relieve psychological anxiety and depression,alleviate body pain,improve quality of life,with significant efficacy.关键词
外阴硬化性苔藓/止痒外阴膏/重组牛碱性成纤维细胞生长因子/中医证候/焦虑抑郁Key words
Vulvar lichen sclerosus/Zhiyang Waiyin ointment/Recombinant bovine basic fibroblast growth factor/Traditional Chinese medicine syndrome/Anxiety and depression分类
医药卫生引用本文复制引用
贾超敏,孙红燕,王莉,董士霞,李一哲,杨慧..止痒外阴膏联合重组牛碱性成纤维细胞生长因子对外阴硬化性苔藓患者中医证候和焦虑抑郁的影响[J].中国医院用药评价与分析,2025,25(3):305-308,4.基金项目
河北省中医药管理局科研计划项目(No.2023363) （No.2023363）
