中国医院用药评价与分析2025，Vol.25Issue(3)：309-312,4.DOI:10.14009/j.issn.1672-2124.2025.03.012
中医定向透药治疗联合三阶梯止痛法对原发性胃癌患者化疗期间癌因性疲乏程度和癌性疼痛改善情况的影响
Effects of Traditional Chinese Medicine Directional Penetration Combined with Three-Step Analgesic Ladder on Cancer-Related Fatigue Degree and Cancer Pain Improvement in Patients with Primary Gastric Cancer During Chemotherapy
摘要
Abstract
OBJECTIVE:To probe into the effects of traditional Chinese medicine directional penetration combined with three-step analgesic ladder on cancer-related fatigue(CRF)degree and cancer pain improvements in patients with primary gastric cancer during chemotherapy.METHODS:A total of 106 patients with primary gastric cancer pain admitted into the hospital from Jun.2022 to Jun.2024 were selected to be divided into the simple analgesia group and penetration analgesia group via random number table method,with 53 cases in each group.The simple analgesia group was given three-step analgesic ladder,while the penetration analgesia group was given traditional Chinese medicine directional penetration combined with three-step analgesic ladder.The pain relief effect,analgesic dosage,changes of cancer pain degrees[Numeric Pain Intensity Scale(NPIS)]and CRF scores before treatment and at the 3rd day and 7th day of treatment were compared between two groups,the levels of pain stress indicators[β-endorphin,calcitonin gene-related peptide(CGRP)and prostaglandin E2(PEG2)]before and after treatment were compared,and the incidences of adverse drug reactions were recorded.RESULTS:The pain relief rate of the penetration analgesia group was 96.23%(51/53),higher than 84.91%(45/53)of the simple analgesia group,with statistically significant difference(χ2=3.975,P<0.05).At the 1st day of treatment,there was no statistically significant difference in the comparison of analgesic dosages between groups(t=1.092,P>0.05),at the 3rd day and 7th day of treatment,the analgesic dosages of the penetration analgesia group were less than those of the simple analgesia group,with statistically significant differences(t were 4.262 and 6.506,respectively,P<0.05).At the 3rd day and 7th day of treatment,the scores of cancer pain NPIS and CRF of the penetration analgesia group were lower than those of the simple analgesia group,with statistically significant differences(at the 3rd day of treatment:t were 5.137 and 10.981,respectively,P<0.05;at the 7th day of treatment:t were 4.878 and 9.159,respectively,P<0.05).After treatment,the β-endorphin level was higher,and the CGRP and PEG2 levels were lower in the penetration analgesia group than those in the simple analgesia group(t were 5.332,5.741 and 5.567,respectively,P<0.05).The incidence of analgesic drug-related adverse drug reactions of the penetration analgesia group was 9.43%(5/53),lower than 24.53%(13/53)of the simple analgesia group,with statistically significant difference(χ2=4.283,P<0.05).CONCLUSIONS:Traditional Chinese medicine directional penetration combined with three-step analgesic ladder can effectively improve cancer pain and CRF during chemotherapy in patients with primary gastric cancer,reduce analgesic dosage and relieve pain stress response,with higher safety.关键词
原发性胃癌/中医定向透药/三阶梯止痛法/癌因性疲乏/癌性疼痛Key words
Primary gastric cancer/Traditional Chinese medicine directional penetration/Three-step analgesic ladder/Cancer-related fatigue/Cancer pain分类
药学引用本文复制引用
董明,雷静,王丽红..中医定向透药治疗联合三阶梯止痛法对原发性胃癌患者化疗期间癌因性疲乏程度和癌性疼痛改善情况的影响[J].中国医院用药评价与分析,2025,25(3):309-312,4.基金项目
2021年河北省医学科学研究课题计划(No.20211071) （No.20211071）
