中国医院用药评价与分析2025，Vol.25Issue(3)：313-316,4.DOI:10.14009/j.issn.1672-2124.2025.03.013
基于PCNE分类系统对2型糖尿病患者进行药学监护的前瞻性观察研究
Prospective Observational Study on Pharmaceutical Care for Patients with Type 2 Diabetes Mellitus Based on PCNE Classification System
摘要
Abstract
OBJECTIVE:To probe into the application value of the Pharmaceutical Care Network of Europe(PCNE)classification system in pharmaceutical care for patients with type 2 diabetes mellitus(T2DM).METHODS:A total of 132 T2DM patients admitted to the hospital from Sept.2021 to Sept.2023 were enrolled to be divided into PCNE group and conventional group via random number table method,with 66 patients in each group.The conventional group was given conventional medical monitoring,while the PCNE group received pharmaceutical care for patients based on the PCNE classification system,the number of drug-related problems(DRPs)were recorded,the causes of problems and propose solutions were analyzed.The 8-item Morisky Medication Adherence Scale(MMAS-8)scores of two groups were compared at admission and 3 months of follow-up after discharge,the blood glucose indicators were observed,the Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)were used to evaluate the changes of patients'mental states.RESULTS:(1)A total of 71 DRPs were found in 66 patients in the PCNE group.①In terms of types of DRPs,it was dominated by treatment effect,which accounted for 66.20%(47 DRPs),treatment safety issues accounted for 21.13%(15 DRPs)and other issues accounted for 12.68%(9 DRPs).②In terms of reasons for DRPs,drug selection accounted for 33.80%(24 DRPs),drug dosage accounted for 42.25%(30 DRPs),treatment course accounted for 9.86%(7 DRPs)and other reasons accounted for 14.08%(10 DRPs).③In terms of interventions,there were 19 patient-level interventions(26.76%),21 physician-level interventions(29.58%)and 31 medication-level interventions(43.66%).④In terms of DRPs intervention acceptance,66 interventions were accepted(92.96%)and 5 interventions were not accepted(7.04%).⑤In terms of status of DRPs,56 problems were fully resolved(78.87%),10 problems were partially resolved(14.08%)and 5 problems were unresolved(7.04%).(2)At 3-month follow-up after discharge,the MMAS-8 scores of both groups were higher than those at admission,and the PCNE group was higher than the conventional group;the fasting blood glucose,glycosylated hemoglobin and 2-h postprandial blood glucose levels were lower than those at admission,and the PCNE group was lower than the conventional group;the SDS and SAS scores were lower than those at admission,and the PCNE group was lower than the conventional group,with statistically significant differences(P<0.05).CONCLUSIONS:The PCNE classification system can be used in the pharmaceutical care for T2DM patients to clarify the number and causes of DRPs,to propose intervention strategies based on DRPs status,to promote patients'treatment adherence,and to improve the blood glucose level and negative emotions.关键词
2型糖尿病/欧洲医药保健网分类系统/药学监护/治疗依从性/负面情绪Key words
Type 2 diabetes mellitus/Pharmaceutical Care Network of Europe classification system/Pharmaceutical care/Treatment adherence/Negative emotion分类
医药卫生引用本文复制引用
马明梅,吉桂芳,李怡瑾,马应俊,徐萌,马晓春..基于PCNE分类系统对2型糖尿病患者进行药学监护的前瞻性观察研究[J].中国医院用药评价与分析,2025,25(3):313-316,4.基金项目
2021年度青海省卫生健康委员会一般指导性计划课题(No.2021-wjzdx-41) （No.2021-wjzdx-41）
