中国医院用药评价与分析2025，Vol.25Issue(3)：325-332,338,9.DOI:10.14009/j.issn.1672-2124.2025.03.016
含独活的中药复方治疗类风湿关节炎的网状Meta分析
Network Meta-Analysis of Traditional Chinese Medicine Compound with Radix Angelicae Biseratae in the Treatment of Rheumatoid Arthritis
摘要
Abstract
OBJECTIVE:To evaluate the efficacy and safety of six kinds of traditional Chinese medicine compound with Bitongkang granules/pills,Bushen decoction and Duhuo Jisheng decoction in the treatment of rheumatoid arthritis based on network Meta-analysis.METHODS:Literature(the retrieval time was from the establishment of the database to Nov.23rd,2023)were retrieved to collect the randomized controlled trials(RCT)of traditional Chinese medicine compound with Radix angelicae biseratae in the treatment of rheumatoid arthritis(the control group was treated with conventional Western medicine,while the observation group received one traditional Chinese medicine compound with Radix angelicae biseratae on the basis of the control group).Cochrane bias risk assessment tool was used to evaluate the quality of RCT,and RevMan 5.3 was used for literature management and quality evaluation.Stata 17.0 software was used to conduct a network Meta-analysis based on the frequency framework of the selected literature.RESULTS:A total of 38 RCT were enrolled,with a total sample size of 3 446 cases,including 1 735 cases in the observation group and 1 711 cases in the control group.According to the area under the cumulative ranking probability curve,Bitongkang granules/pills+conventional Western medicine was the most effective intervention to improve the clinical efficiency;in terms of reducing rheumatoid factors,Bushen decoction+conventional Western medicine were the most effective intervention measures;in terms of improving serum erythrocyte sedimentation rate,Duhuo Jisheng decoction+conventional Western medicine were the most effective intervention measures;in terms of improving C-reactive protein,Sanbi decoction+conventional Western medicine was the most effective intervention measures.CONCLUSIONS:Traditional Chinese medicine compound with Radix angelicae biseratae combined with conventional Western medicine in the treatment of rheumatoid arthritis can reduce the adverse drug reactions of patients and the therapeutic effect is better than that of conventional Western medicine alone.However,due to the lack of direct comparison among different drugs,the low overall quality of the included literature and the limited number of included literature and cases,the above conclusions still need to be further verified.关键词
独活/类风湿关节炎/联合治疗/网状Meta分析Key words
Radix angelicae biseratae/Rheumatoid arthritis/Combination therapy/Network Meta-analysis分类
医药卫生引用本文复制引用
任鹏飞,刘铭,文武龙,张炜烨,杨婧,王锐..含独活的中药复方治疗类风湿关节炎的网状Meta分析[J].中国医院用药评价与分析,2025,25(3):325-332,338,9.基金项目
国家自然科学基金资助项目(No.82074271) （No.82074271）
