中国医院用药评价与分析2025，Vol.25Issue(3)：333-338,6.DOI:10.14009/j.issn.1672-2124.2025.03.017
贝前列素钠联合前列地尔治疗糖尿病肾病的有效性和安全性的系统评价与Meta分析
Systematic Review and Meta-Analysis on Efficacy and Safety of Beraprost Sodium Combined with Alprostadil in the Treatment of Diabetic Nephropathy
摘要
Abstract
OBJECTIVE:To systematically review the efficacy and safety of beraprost sodium combined with alprostadil in the treatment of diabetic nephropathy.METHODS:Chinese and foreign databases such as CNKI,Wanfang Data,Embase,PubMed and the Cochrane Library were retrieved to collect the randomized controlled trials(RCT)of beraprost sodium combined with alprostadil in the treatment of diabetic nephropathy(the intervention measures of the study group were conventional treatment+alprostadil+beraprost sodium,while the control group received conventional treatment+alprostadil).The retrieval time was from the establishment of the database to Mar.31st,2024.The Cochrane systematic review manual was used for literature screening,quality evaluation and data extraction.Meta-analysis was performed by using RevMan 5.4 and Stata 17.0 software.RESULTS:A total of 20 articles were included,with a total of 2 213 patients.Meta-analysis showed that 24 h urinary protein quantification,urinary microalbumin,urinary albumin excretion rate,urea nitrogen,serum creatinine,cystatin C,inflammatory factor levels(C-reactive protein,interleukin 6,and tumor necrosis factor α)and lipid levels(total cholesterol,triglyceride,low-density lipoprotein cholesterol and high-density lipoprotein cholesterol)in the treatment group were better than those in the control group,with statistically significant differences(P<0.05).There was no significant difference in the incidence of adverse drug reactions between control group and study group(P=0.77),and the combination of two drugs did not increase the risk of adverse drug reactions.CONCLUSIONS:Beraprost sodium combined with alprostadil is superior to alprostadil in improving the levels of 24 h urinary protein quantification,urinary microalbumin,urinary albumin excretion rate,urea nitrogen,serum creatinine,cystatin C,inflammatory factors,and lipid indicators in patients with diabetic nephropathy,and it has better clinical efficacy than alprostadil.关键词
糖尿病肾病/前列地尔/贝前列素钠/Meta分析Key words
Diabetic nephropathy/Alprostadil/Beraprost sodium/Meta-analysis分类
医药卫生引用本文复制引用
合颖佳,刘品麟,樊文星..贝前列素钠联合前列地尔治疗糖尿病肾病的有效性和安全性的系统评价与Meta分析[J].中国医院用药评价与分析,2025,25(3):333-338,6.基金项目
云南省中青年学术和技术带头人后备人才项目(No.202205AC160062) （No.202205AC160062）
昆明医科大学第一附属医院"535"高层次人才培养项目(No.2022535D06) （No.2022535D06）
昆明医科大学中青年学科带头人及后备人选——"乘风"人才培养计划 （）
