中国医院用药评价与分析2025，Vol.25Issue(3)：339-342,4.DOI:10.14009/j.issn.1672-2124.2025.03.018
局部应用他克莫司治疗口腔扁平苔藓的快速卫生技术评估
Rapid Health Technology Assessment of Topical Tacrolimus in the Treatment of Oral Lichen Planus
摘要
Abstract
OBJECTIVE:To rapidly evaluate the efficacy,safety and economy of topical tacrolimus in the treatment of oral lichen planus,and provide evidence-based support for oral clinical medication.METHODS:Chinese and English databases such as CNKI,Wanfang Data,VIP,CBM,PubMed,Embase,the Cochrane Library and the Health Technology Assessment(HTA)official website were searched to collect HTA reports,systematic review/Meta-analysis and pharmacoeconomic studies on tacrolimus treatment of oral lichen planus.The retrieval time was from the establishment of the database to Sept.14th,2024.The qualitative description method was used to summarize the included studies,and relevant scales were used to analyse the literature and its methodology.RESULTS:A total of 13 systematic reviews/Meta-analyses were included,of which 1 systematic review/Meta-analysis also included a pharmacoeconomic review,and no HTA reports were retrieved.In terms of efficacy in the treatment of oral lichen planus,tacrolimus was significantly better than placebo in improving clinical scores and pain scores,and the efficacy was no less than glucocorticoids.The relapse rate of tacrolimus withdrawal was not higher than that of glucocorticoids.In terms of safety,tacrolimus was associated with low incidence of adverse drug reactions and good safety.Compared with glucocorticoids,the clinical efficacy and safety of tacrolimus in the treatment of oral lichen planus was still controversial.In terms of economy,tacrolimus was less economical than glucocorticoids(dexamethasone,clobetasol,triamcinolone acetonide),but more cost-effective than pimecrolimus and cyclosporine.CONCLUSIONS:Topical tacrolimus in the treatment of oral lichen planus has good efficacy and safety,and it is necessary to carry out pharmacoeconomic research in the future.关键词
他克莫司/口腔扁平苔藓/快速卫生技术评估Key words
Tacrolimus/Oral lichen planus/Rapid health technology assessment分类
医药卫生引用本文复制引用
汪星,陈雪茹,郭锦材..局部应用他克莫司治疗口腔扁平苔藓的快速卫生技术评估[J].中国医院用药评价与分析,2025,25(3):339-342,4.基金项目
湖南省自然科学基金资助项目(No.2024JJ9532) （No.2024JJ9532）
湖南中医药大学校院联合基金项目(No.2022XYLH134) （No.2022XYLH134）
