中国医院用药评价与分析2025，Vol.25Issue(3)：346-351,6.DOI:10.14009/j.issn.1672-2124.2025.03.020
阿片类镇痛药用于慢性非癌性疼痛的药物临床综合评价
Clinical Comprehensive Evaluation on Opioid Analgesics for Chronic Non-Cancer Pain
那一凡 1姜文亮 1杨雪 1夏路风 1常涛 1谭玲1
作者信息
- 1. 北京医院药学部,药物临床风险与个体化应用评价北京市重点实验室,国家老年医学中心,中国医学科学院老年医学研究所,北京 100730
- 折叠
摘要
Abstract
OBJECTIVE:Based on A Quick Guideline for Drug Evaluation and Selection in Chinese Medical Institutions(the Second Edition),to conduct a comprehensive evaluation on opioid analgesics approved for the treatment of chronic non-cancer pain in China,so as to provide reference for the drug selection and medication decision-making in medical institutions.METHODS:Evaluative evidence was collected through the informatization platform of relevant authoritative institutions,and the enrolled drugs were scored in 5 aspects,including effectiveness,safety,pharmacological properties,economical efficiency and other attributes.RESULTS:Through quantitative scoring,the average score of opioid analgesics enrolled in the evaluation was 50.83 points.However,there was a large gap between different drugs,among which fentanyl transdermal patch had a high formulation safety and a wide range of applicability,with the highest comprehensive score of 62.27 points;tramadol hydrochloride for injection had the lowest score of 36.28 points.CONCLUSIONS:Opioid analgesics are the second-line drugs for the treatment of chronic noncancer pain.Opioid analgesics can be used for the treatment of patients who are ineffective after non-pharmacologic treatment and non-opioid analgesic treatment.Fentanyl transdermal patche can safely and effectively relieve pain in patients,but attention should still be paid to regularly evaluate the risk and efficacy of patients to avoid the occurrence of severe adverse drug reactions.关键词
阿片类镇痛药/慢性非癌性疼痛/综合评价Key words
Opioid analgesics/Chronic non-cancer pain/Comprehensive evaluation分类
医药卫生引用本文复制引用
那一凡,姜文亮,杨雪,夏路风,常涛,谭玲..阿片类镇痛药用于慢性非癌性疼痛的药物临床综合评价[J].中国医院用药评价与分析,2025,25(3):346-351,6.
