中国临床药理学与治疗学2025，Vol.30Issue(4)：446-455,10.DOI:10.12092/j.issn.1009-2501.2025.04.002
白细胞计数与静脉血栓栓塞的关联:双向孟德尔随机化研究
Association of white blood cell count with venous thromboembo-lism:a two-way Mendelian randomization study
摘要
Abstract
AIM:To explore the causal association between the counts of five types of white blood cells—neutrophils,monocytes,eosinophils,baso-phils,and lymphocytes—and venous thromboem-bolism(VTE).METHODS:Mendelian randomization(MR)analysis method was used,with genetic vari-ants associated with the five types of white blood cells as instrumental variables,and venous throm-boembolism occurrence risk as the outcome vari-able,inverse variance-weighted(IVW)method was employed as the primary analysis method,with MR-Egger regression,weighted median(WM),sim-ple model,and weighted mode methods used as supplements,to analyze the causal association be-tween the counts of five types of white blood cells and VTE,followed by reverse MR analysis.RE-SULTS:Neutrophil and lymphocyte counts are caus-ally associated with the risk of VTE.For neutrophil count,the IVW estimate(OR=0.867,95%CI:0.761-0.981,P=0.031),MR-Egger estimate(OR=0.754,95%CI:0.571-0.996,P=0.048),weighted median es-timate(OR=0.846,95%CI:0.729-0.981,P=0.027),and weighted model estimate(OR=0.748,95%CI:0.595-0.942,P=0.014)were calculated.For lympho-cyte count,the IVW estimate(OR=0.838,95%CI:0.741-0.949,P=0.005)and weighted median esti-mate(OR=0.024,95%CI:0.718-0.977,P=0.024)were calculated.Reverse MR analysis showed a causal association between the risk of VTE and neu-trophil count,the IVW estimate(OR=0.989,95%CI:0.980-0.999,P=0.024).CONCLUSION:Neutrophil and lymphocyte counts are related to the risk of VTE,and decrease in neutrophil and lymphocyte numbers may increase the risk of VTE.VTE occur-rence risk is associated with neutrophil count,and reducing the risk of VTE occurrence may increase neutrophil count.Further research is needed to un-derstand the underlying biological mechanisms be-hind this relationship.关键词
静脉血栓栓塞/血栓栓塞疾病/白细胞计数/孟德尔随机化Key words
venous thromboembolism/thrombo-embolic disease/white blood cell count/Mendelian randomization分类
药学引用本文复制引用
郭展立,王媛,张磊,李嘉媛,李若柠,冬颖,孙建军..白细胞计数与静脉血栓栓塞的关联:双向孟德尔随机化研究[J].中国临床药理学与治疗学,2025,30(4):446-455,10.基金项目
国家自然科学基金地区项目(81960770) （81960770）
内蒙古自治区卫生健康科技计划项目(202202184) （202202184）
内蒙古自治区"草原英才"工程青年创新人才(一层次)支持项目(Q2022084) （一层次）
内蒙古医科大学重点项目(YKD2023ZD002) （YKD2023ZD002）
内蒙古医科大学"致远"人才项目(ZY20242133) （ZY20242133）
内蒙古自治区高等学校科学研究项目(NJZY22623) （NJZY22623）
