中国医院用药评价与分析2025，Vol.25Issue(3)：376-380,5.DOI:10.14009/j.issn.1672-2124.2025.03.026
卡博替尼治疗肝癌的多靶点作用及其研究进展
Multi-Target Effects of Cabozantinib in the Treatment of Hepatocellular Carcinoma and Its Research Progress
摘要
Abstract
This article performs a systematic review on the multi-targeted effects of cabozantinib in the treatment of hepatocellular carcinoma and its latest research progress,so as to evaluate its efficacy in inhibiting tumor angiogenesis,modulating the tumor microenvironment and suppressing tumor cell growth,as well as explore the mechanisms of drug resistance and the direction of future development.Through literature and clinical research data in recent years,this article analyzes the molecular targets and the multilevel anti-tumor effects of cabozantinib,and summarizes its efficacy and safety in various stages of clinical application.Meanwhile,this article investigates the combination therapy strategy,drug resistance mechanism and novel drug delivery technology of cabozantinib.Cabozantinib significantly inhibits tumor angiogenesis,cell proliferation and metastasis,optimizes the tumor immune microenvironment by inhibiting various signaling pathways including vascular endothelial growth factor receptor,hepatocyte growth factor receptor and Anexelekto.Clinical data indicates that cabozantinib demonstrates high disease control rate and survival benefit in multiline treatment of advanced hepatocellular carcinoma.However,drug resistance emerges as the treatment is prolonged,and adverse effects such as hypertension and hand-foot syndrome need to be managed.Cabozantinib has showed multi-targeted anti-tumor potential in hepatocellular carcinoma treatment,and future studies should focus on the resolution of resistance mechanisms,the development of novel combination therapies and the application of biomarkers,as well as the exploration of nanotechnology and other novel drug delivery ways,so as to improve efficacy and safety.Multi-pathway interventions will help promote new breakthroughs in hepatocellular carcinoma treatment.关键词
卡博替尼/肝细胞癌/多靶点抑制/耐药机制/生物标志物/新型给药技术Key words
Cabozantinib/Hepatocellular carcinoma/Multi-target inhibition/Resistance mechanisms/Biomarkers/Novel drug delivery technology分类
药学引用本文复制引用
王佩佩,单亮,谢林虎..卡博替尼治疗肝癌的多靶点作用及其研究进展[J].中国医院用药评价与分析,2025,25(3):376-380,5.基金项目
安徽省卫生健康科研项目计划项目(No.AHWJ2023BAc20099) （No.AHWJ2023BAc20099）
