中国临床药理学与治疗学2025，Vol.30Issue(4)：477-486,10.DOI:10.12092/j.issn.1009-2501.2025.04.005
SMARCA4缺失型非小细胞肺癌的SPP1表达及其与PD-L1的关系
SPP1 expression in SMARCA4-deficient non-small cell lung cancer and its relationship with PD-L1
摘要
Abstract
AIM:To analyze the expression of se-creted phosphoprotein 1(SPP1)and programmed cell death-ligand 1(PD-L1)in SMARCA4-deficient non-small cell lung cancer,and to provide a scientif-ic basis for the study of the follow-up treatment of this rare pathological type of lung cancer.METH-ODS:The clinical and pathological characteristics of 12 patients with this disease were analyzed retro-spectively,and the patients were divided into two groups of adenocarcinomas and poorly differentiat-ed carcinomas according to their morphological characteristics,and the relationship between the expression of SPP1 and PD-L1 was analyzed in the two groups.RESULTS:SPP1 expression was detect-ed in all patients and Its expression level was signif-icantly higher in the poorly differentiated carcino-ma group compared with the adenocarcinoma group(P=0.015);PD-L1 expression was found in 6/7 patients(5 cases were not measured),compared with the adenocarcinoma group,PD-L1 was also highly expressed in the poorly differentiated carci-noma group(P=0.048)and the PD-L1 difference be-tween the two groups suggested that the results were similar to those of SPP1.CONCLUSION:SMARCA4-deficient non-small cell lung cancer has high positive expression of SPP1 and PD-L1.It was more pronounced in patients with poorly differenti-ated carcinoma.There may be a positive correla-tion between SPP1 and PD-L1 expression in SMAR-CA4-deficient non-small cell lung cancer and the mechanism of the correlation needs to be further verified in subsequent studies.关键词
NSCLC/SMARCA4缺失/SPP1/PD-L1/免疫治疗Key words
NSCLC/SMARCA4 deficient/SPP1/PD-L1/immunotherapy分类
药学引用本文复制引用
吴娟,黄曦,李佳嘉,魏雨晴,张丽琴,俞咏梅,陆志伟,张鹤..SMARCA4缺失型非小细胞肺癌的SPP1表达及其与PD-L1的关系[J].中国临床药理学与治疗学,2025,30(4):477-486,10.基金项目
2024年度安徽省高校科研项目(2024AH051949) （2024AH051949）
2022年皖南医学院自然科学研究重点项目(WK2022Z11) （WK2022Z11）
2021年安徽省教育厅重大项目(KJ2021ZD0105) （KJ2021ZD0105）
