中国临床药理学与治疗学2025，Vol.30Issue(4)：509-516,8.DOI:10.12092/j.issn.1009-2501.2025.04.009
肠菌移植联合免疫检查点抑制剂在终末期恶性肿瘤患者治疗中的探索性研究
Exploratory study of fecal microbiota transplantation combined with immune checkpoint inhibitors in the treatment of end-stage malig-nant tumor patients
摘要
Abstract
AIM:To explore the efficacy and safe-ty of fecal microbiota transplantation combined with immune checkpoint inhibitors(ICIs)for malig-nant tumor patients with failed multi line anti-tu-mor treatment and concomitant cachexia,and to explore the changes in blood immunity and intesti-nal microbial environment in patients.METHODS:Five patients with malignant tumors who failed multi line anti-tumor treatment were enrolled and treated with ICIs combined with fecal microbiota transplantation.The efficacy was evaluated every 2-3 cycles,and adverse reactions were observed.Fe-cal 16srRNA gene sequencing and serum immuno-logical indicators were dynamically detected.RE-SULTS:Except for one patient who died 2.5 months after transplantation due to excessive tumor bur-den at enrollment,the overall survival of the re-maining four patients were extended(7.4,8.3,28.5,52.3 months).One patient with multiple intra-cranial metastases of lung adenocarcinoma signifi-cantly reduced the intracranial metastasis after in-testinal microbiota transplantation and almost dis-appeared.The serum IL-2,IL-10,TGF-β and other indicators of patients increased rapidly and then slowly decreased with the increase of transplanta-tion time,and finally were higher than before trans-plantation,with statistical differences.16srRNA gene sequencing analysis revealed significant differ-ences in the overall distribution of gut microbiota in patients after transplantation,gradually ap-proaching healthy transplant donors.All patients did not experience grade 2 or above adverse reac-tions,and the safety was good.CONCLUSION:For patients with malignant tumors,the combination of fecal microbiota transplantation and immuno-therapy may improve their quality of life,serum im-mune environment,and intestinal microbiota com-position,have a positive impact on survival progno-sis,and are safe and controllable,opening up new treatment methods for end-stage patients.关键词
肠菌移植/免疫检查点抑制剂/多线治疗/恶性肿瘤Key words
fecal microbiota transplant/immuno-therapy/multi line treatment/malignant tumor分类
临床医学引用本文复制引用
储云茜,薛雅,蒋华,戚春建,戴菡珏,仙晴颖,朱文宇..肠菌移植联合免疫检查点抑制剂在终末期恶性肿瘤患者治疗中的探索性研究[J].中国临床药理学与治疗学,2025,30(4):509-516,8.基金项目
江苏省卫生健康委科研项目(ZD2022035) （ZD2022035）
南京医科大学项目(NMUB20210052) （NMUB20210052）
