中国临床药理学与治疗学2025，Vol.30Issue(4)：517-525,9.DOI:10.12092/j.issn.1009-2501.2025.04.010
表观遗传学在抑郁症发病机制中的研究进展
Research progress of epigenetics in the pathogenesis of depression
摘要
Abstract
Depression is a mental disease with in-creasing prevalence worldwide,which seriously en-dangers human health with high disability rate and high suicide rate.Epigenetics is an emerging genet-ic theory in the 21st century.Its main research con-tent is to regulate the process of gene transcription or translation and affect its function and character-istics without changing the DNA sequence.These include DNA methylation,histone modification,chromatin remodeling and non-coding RNA regula-tion.The nervous system is susceptible to changes in the activity of epigenetic modifiers,and an in-creasing number of studies have shown that genet-ics and environment play an important role in the development of depression.This review will focus on the epigenetic mechanisms of depression.关键词
抑郁症/表观遗传学/DNA甲基化/组蛋白修饰/非编码RNA调控/染色质重塑Key words
depression/epigenetics/DNA methyl-ation/histone modification/noncoding RNA regula-tion/chromatin remodeling分类
临床医学引用本文复制引用
张瑶,邹蔓姝,韩远山,王宇红..表观遗传学在抑郁症发病机制中的研究进展[J].中国临床药理学与治疗学,2025,30(4):517-525,9.基金项目
国家自然科学基金项目(82174357) （82174357）
湖南省中医药管理局科研项目(B2023141) （B2023141）
湖南省科药联合基金(2023JJ60476) （2023JJ60476）
湖南省教育厅优秀青年基金(23B0360,24B0342) （23B0360,24B0342）
湖南中医药大学研究生创新课题(2024CX199) （2024CX199）
