中国临床药理学与治疗学2025，Vol.30Issue(4)：526-532,7.DOI:10.12092/j.issn.1009-2501.2025.04.011
支链氨基酸和芳香族氨基酸对2型糖尿病作用进展
Effects of branched-chain and aromatic amino acids on type 2 diabe-tes mellitus and the progress
摘要
Abstract
Type 2 diabetes mellitus is a metabol-ic disease characterized by high blood sugar levels.Traditionally,amino acids are primarily viewed as the basic building blocks for proteins and peptide synthesis.However,in recent years,amino acids have gained increased attention as signaling mole-cules that play crucial roles in the maintenance and regulation of metabolic homeostasis.It has been found that there is a close correlation between the metabolism of branched-chain and/or aromatic amino acids and the occurrence or development of type 2 diabetes mellitus.Furthermore,there have been successive reports on the regulation mecha-nism involved.This article will focus on the meta-bolic processes,mechanisms and clinical value of branched-chain and aromatic amino acids in type 2 diabetes mellitus.It will also summarize and pro-vide an outlook on the current state of amino acid metabolism in the treatment of diabetes mellitus,with the aim of offering new ideas for the treat-ment of type 2 diabetes mellitus.关键词
支链氨基酸/芳香族氨基酸/代谢紊乱/2型糖尿病/胰岛素抵抗Key words
branched-chain amino acids/aromat-ic amino acids/metabolic disorders/type 2 diabe-tes mellitus/insulin resistance分类
医药卫生引用本文复制引用
张孟丽,吴芳芳,谭栀恩,欧敏,刘灵杰,陆纳,乔丽娅,杨晓男..支链氨基酸和芳香族氨基酸对2型糖尿病作用进展[J].中国临床药理学与治疗学,2025,30(4):526-532,7.基金项目
国家自然科学基金(82360767) （82360767）
广西中医药管理局自筹经费科研课题(GXZYA20230005、GXZYA20220010) （GXZYA20230005、GXZYA20220010）
广西药用植物园科研基金项目(桂药基2020010、桂药青岐202403) （桂药基2020010、桂药青岐202403）
