中国临床药理学与治疗学2025，Vol.30Issue(4)：548-555,8.DOI:10.12092/j.issn.1009-2501.2025.04.014
巨噬细胞极化与心血管疾病研究进展
Research progress on the role of macrophage polarization in cardio-vascular diseases
摘要
Abstract
As phagocytic innate immune cells,macrophages interact with various tissue types and play an important role in immune defense,inflam-matory response and tissue remodeling.Macro-phages participate in the occurrence and develop-ment of disease by polarizing into classically acti-vated M1 type and substitutively activated M2 type,or more complex phenotypes,when the tis-sue microenvironment changes.This paper focused on the application of macrophage polarization in cardiovascular diseases,and introduces macro-phage origin and activation to propose the relation-ship between macrophage polarization and cardio-vascular diseases.Then,the strategies for targeted macrophage therapy were proposed to provide an important theoretical basis for improving the in-flammatory state of cardiovascular diseases.关键词
巨噬细胞极化/炎症/心血管疾病/转录调控Key words
macrophage polarization/inflamma-tion/cardiovascular diseases/transcriptional regula-tion分类
医药卫生引用本文复制引用
崔涵雨,胡长平..巨噬细胞极化与心血管疾病研究进展[J].中国临床药理学与治疗学,2025,30(4):548-555,8.基金项目
国家自然科学基金资助项目(82241025) （82241025）
