摘要
Abstract
Objective:To explore the clinical effect of different doses of Pulmonary surfactant(PS)combined with non-invasive high frequency oscillatory ventilation(NHFOV)on respiratory distress syndrome(RDS)of premature infants.Method:A total of 60 children with RDS treated in Daye People's Hospital from January 2020 to June 2023 were selected as the study objects and divided into control group and observation group according to random number table,with 30 cases in each group.The two groups were treated with PS combined with NHFOV on the basis of conventional treatment,in which the control group was given a low dose of PS(100 mg/kg)and the observation group was given a high dose of PS(150 mg/kg).The clinical efficacy,mechanical ventilation parameters[respiratory rate(RR),inhaled oxygen concentration(FiO2),positive end-expiratory pressure(PEEP),peak inspiratory pressure(PIP)],blood gas indexes[pH value,arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)]and the incidence of complications were compared between the two groups before treatment and 3 days after treatment.Result:After treatment,the clinical efficacy of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of RR,FiO2,PEEP and PIP in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).After treatment,pH and PaO2 in observation group were higher than those in control group,and PaCO2 was lower than those in control group,and the difference was statistically significant(P<0.05).After treatment,the incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:High-dose PS combined with NHFOV is effective in the treatment of RDS children,which can effectively improve the mechanical ventilation parameters and blood gas indexes of children,reduce the incidence of complications,and facilitate rehabilitation.关键词
肺表面活性物质/NHFOV/早产儿呼吸窘迫综合征/临床研究Key words
Pulmonary surfactant/NHFOV/Respiratory distress syndrome of premature infants/Clinical research
