中国医药科学2025，Vol.15Issue(5)：21-24,4.DOI:10.20116/j.issn2095-0616.2025.05.05
运动因子鸢尾素改善阿尔茨海默病认知障碍的作用机制
Function mechanism of irisin as a motion factor in the improvement of cognitive impairment in Alzheimer's disease
摘要
Abstract
With the acceleration of global population aging,Alzheimer's disease(AD)has become one of the major public health problems that endanger the health of the elderly in China and even the whole world,and there is no effective treatment now.Irisin is a hormone related to motion,which plays an important function in regulating inflammatory response,oxidative stress and synaptic plasticity in hippocampus.The function mechanism of irisin as a motion factor in the improvement of cognitive impairment in AD is described in this review.Irisin enhances learning and memory ability by up-regulating neurotrophic factors,inhibiting oxidative stress and neuroinflammation,improving blood-brain barrier function and reducing neuron death.关键词
鸢尾素/阿尔茨海默病/认知障碍/运动Key words
Irisin/Alzheimer's disease/Cognitive impairment/Motion分类
医药卫生引用本文复制引用
李其琪,李茂全..运动因子鸢尾素改善阿尔茨海默病认知障碍的作用机制[J].中国医药科学,2025,15(5):21-24,4.基金项目
四川省中医药管理局项目资助(2023MS097). （2023MS097）
