中国医药科学2025，Vol.15Issue(5)：57-60,118,5.DOI:10.20116/j.issn2095-0616.2025.05.14
基于网络药理学探讨特色蒙药山沉香治疗心肌缺血的作用机制
Investigation on the function mechanism of the characteristic Mongolian medicine Syringa pinnatifolia in the treatment of myocardial ischemia based on network pharmacology
摘要
Abstract
Objective To investigate the molecular function mechanism of the characteristic Mongolian medicine Syringa pinnatifolia in the treatment of myocardial ischemia.Methods The chemical components of Syringa pinnatifolia were collected through literature mining and database retrieval,and target prediction of target compounds was performed using online platforms such as SWISS and Superpred.Targets related to myocardial ischemia relevant diseases and pathogenesis using the OMIM database were retrieved and organized,and Venn maps using the EVenn online mapping tool were created to obtain cross targets between the active ingredient target genes of Syringa pinnatifolia and the myocardial ischemia related target genes,namely key targets.Target function enrichment analysis was performed on key targets of Syringa pinnatifolia using the DAVID database,signaling pathways related to myocardial ischemia were screened,and the results by drawing a bioinformatics diagram were visualized.A network model of"compound-key target-signal pathway"was constructed using Cytoscape software,and the Schrodinger program was used to perform molecular docking verification between the active ingredients of Syringa pinnatifolia and key targets.Results A total of 55 active ingredients from Aquilaria sinensis were collected,with 1,394 predicted compound targets,1,022 targets for myocardial ischemia disease and its pathogenesis,and 132 cross targets between compounds and diseases.The results of network pharmacology showed that the biological pathways of Syringa pinnatifolia related to myocardial ischemia disease might include inflammatory reaction,stress reaction,apoptosis,atherosclerosis,endocrine regulation,etc.The PI3K-Akt signaling pathway may be the main pathway through which Syringa pinnatifolia exerts its pharmacological effects in the treatment of myocardial ischemia.Conclusion Aquilaria sinensis may play a role in the treatment of myocardial ischemia through inflammatory reaction,stress reaction,apoptosis,atherosclerosis,endocrine regulation,etc.关键词
蒙药/山沉香/网络药理学/心肌缺血/作用机制Key words
Mongolian medicine/Syringa pinnatifolia/Network pharmacology/Myocardial ischemia/Function mechanism分类
医药卫生引用本文复制引用
孙雨辉,王春媛,刘巾玮,王东娜,王旭梅,陆景坤,苏柯萌,祁孟然,梁凤娟..基于网络药理学探讨特色蒙药山沉香治疗心肌缺血的作用机制[J].中国医药科学,2025,15(5):57-60,118,5.基金项目
内蒙古自治区赤峰市自然科学科研立项课题(SZR2023090). （SZR2023090）
