中国药业2025，Vol.34Issue(7)：93-96,4.DOI:10.3969/j.issn.1006-4931.2025.07.020
司美格鲁肽注射液治疗2型糖尿病合并阻塞性睡眠呼吸暂停低通气综合征临床观察
Clinical Observation of Semaglutide Injection in the Treatment of Type 2 Diabetes Mellitus Complicated with Obstructive Sleep Apnea-Hypopnea Syndrome
摘要
Abstract
Objective To investigate the effect of semaglutide injection on blood glucose,blood lipids,respiratory parameters,and body weight in patients with type 2 diabetes mellitus(T2DM)complicated with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods A total of 112 patients with T2DM complicated with OSAHS admitted to the hospital from April 2022 to July 2023 were selected and divided into the observation group(63 cases)and the control group(49 cases)based on different hypoglycemic regimens.The patients in the observation group received semaglutide therapy,while the patients in the control group received conventional hypoglycemic therapy.Both groups were treated continuously for 24 weeks.Results After treatment,the fasting blood glucose(FBG),2 h postprandial blood glucose(2 hPG),glycated hemoglobin(HbA1C),total cholesterol(TC),triglycerides(TG),body mass,apnea-hypopnea index(AHI),and interleukin-6(IL-6)levels in the two groups significantly decreased(P<0.05);the lowest pulse oxygen saturation(LSpO₂)and fasting C-peptide(FC-P)levels in the two groups significantly increased(P<0.05),and the levels of 2 hPG,HbA1C,TC,TG,AHI,IL-6,and body mass in the observation group were significantly lower than those in the control group(P<0.05),while the FC-P level in the observation group was significantly higher than that in the control group(P<0.05).The incidence of adverse reactions was comparable between the observation group and the control group(6.35%vs.2.04%,P>0.05).Conclusion Semaglutide in the treatment of T2DM complicated with OSAHS has good efficacy and safety,which can effectively control blood glucose,improve blood lipids and hypoxia,and reduce the severity of sleep apnea.关键词
司美格鲁肽/2型糖尿病/阻塞性睡眠呼吸暂停低通气综合征/血糖/血脂/呼吸暂停低通气指数Key words
semaglutide/type 2 diabetes mellitus/obstructive sleep apnea-hypopnea syndrome/blood glucose/blood lipid/apnea-hypopnea index分类
医药卫生引用本文复制引用
周蓉敏,肖秘苏,赵贇,成佩秋,张剑萍,郭澄..司美格鲁肽注射液治疗2型糖尿病合并阻塞性睡眠呼吸暂停低通气综合征临床观察[J].中国药业,2025,34(7):93-96,4.基金项目
国家自然科学基金面上项目[81873042] （）
上海交通大学附属第六人民医院院级回顾性临床研究课题[沪六院内科字(2020)第1号] （2020）
上海交通大学医学院青年科技创新工作室项目[沪交医团[2022]24号]. （）
