中国药业2025，Vol.34Issue(7)：96-100,5.DOI:10.3969/j.issn.1006-4931.2025.07.021
滋肾健脾养宫汤联合来曲唑治疗肾虚血瘀证多囊卵巢综合征临床研究
Clinical Study of Zishen Jianpi Yanggong Decoction Combined with Letrozole in the Treatment of Polycystic Ovary Syndrome with Kidney Deficiency and Blood Stasis Syndrome
摘要
Abstract
Objective To investigate the clinical efficacy of Zishen Jianpi Yanggong Decoction combined with letrozole in the treatment of polycystic ovary syndrome(PCOS)with kidney deficiency and blood stasis syndrome,and its effect on the gut-brain axis and hemorheological indexes.Methods A total of 110 PCOS patients with kidney deficiency and blood stasis syndrome admitted to the Cangzhou People's Hospital and Cangzhou Central Hospital from June 2021 to December 2022 were selected and divided into the control group(52 cases)and the observation group(58 cases)based on treatment regimens.The patients in the two groups received letrozole,while the patients in the observation group additionally received Zishen Jianpi Yanggong Decoction.Both groups were continuously treated for three menstrual cycles.Results The total effective rate in the observation group was 91.38%,which was significantly higher than 73.08%in the control group(P<0.05).After treatment,the hirsutism and acne scores,left and right ovarian volumes in the two groups significantly decreased(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05);the levels of luteinizing hormone(LH),testosterone,and LH/follicle-stimulating hormone(FSH)in the two groups significantly decreased,while the level of estradiol in the two groups significantly increased(P<0.05),and those in the observation group were significantly better than those in the control group(P<0.05);the high-and low-shear whole blood viscosity,erythrocyte sedimentation rate,and hematocrit in the two groups significantly decreased(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05);the levels of ghrelin,glucagon-like peptide-1(GLP-1),peptide YY(PYY),and short-chain fatty acid in the two groups significantly increased(P<0.05),and those in the observation group were significantly higher than those in the control group(P<0.05);the traditional Chinese Medicine(TCM)syndrome score in the two groups significantly decreased(P<0.05),and that in the observation group was significantly lower than that in the control group(P<0.05).The incidence of adverse reactions was comparable between the observation group and the control group(13.79%vs.13.46%,P>0.05).Conclusion Zishen Jianpi Yanggong Decoction combined with letrozole in the treatment of PCOS with kidney deficiency and blood stasis syndrome has good efficacy and safety,which can effectively regulate the gut-brain axis,endocrine metabolism,and sex hormone levels,and improve menstrual conditions and hemorheological indexes.关键词
滋肾健脾养宫汤/来曲唑/多囊卵巢综合征/肾虚血瘀证/血液流变学/肠-脑轴Key words
Zishen Jianpi Yanggong Decoction/letrozole/polycystic ovary syndrome/kidney deficiency and blood stasis syndrome/hemorheology/gut-brain axis分类
药学引用本文复制引用
侯志敏,高洁凡,宋阳阳,黄晓..滋肾健脾养宫汤联合来曲唑治疗肾虚血瘀证多囊卵巢综合征临床研究[J].中国药业,2025,34(7):96-100,5.基金项目
河北省医学科学研究课题[20220341]. （）
