摘要
Abstract
Objective:To analyze the effects of combination therapy with linezolid and cycloserine capsules on X-pert MTB/RIF test results and lung function levels in patients with multidrug-resistant pulmonary tuberculosis.Method:79 patients with multidrug-resistant tuberculosis admitted to Jinjiang Hospital from July 2021 to June 2023 were selected as the study objects for retrospective treatment study.All patients received investigatory drug treatment during this period.The patients treated with Elinezolid were the reference group(39 cases),and the patients treated with Elinezolid combined with cycloserine capsule were the study group(40 cases).The levels of lung ventilation function and cellular immune function before and after treatment were compared between the two groups.After treatment,the results of X-pert MTB/RIF detection,the improvement time of clinical symptoms,the negative conversion rate of tuberculosis in sputum,the effective rate of treatment and the incidence of adverse drug reactions.Result:Compared with the control group,the levels of ventilatory function,CD4+,CD8+and CD4+/CD8+in the study group after cycloserine combined treatment were increased,and the differences were statistically significant(P<0.05).The positive detection rate of X-pert MTB/RIF was decreased(15.00%),the negative conversion rate of sputum tuberculosis bacillus was increased(85.00%),and the effective rate of treatment was increased(92.50%),with statistical significance(P<0.05).The time of focal area reduction,sputum culture to negative time,acid-fast staining smear to negative time and pulmonary cavity closure time were shortened,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion:The combined treatment of linezolid and cycloserine capsule in patients with MDR-TB has a definite effect,which can reduce the positive detection rate of X-pert MTB/RIF,promote the negative transformation of sputum tuberculosis,and regulate the lung function and cellular immune function of patients,without obvious risk of toxic and side effects,and has clinical safety.关键词
利奈唑胺/环丝氨酸/多耐药肺结核/X-pert MTB/RIF/肺功能Key words
Linezolid/Cycloserine/Multidrug resistant pulmonary tuberculosis/X-pert MTB/RIF/Pulmonary function
