摘要
Abstract
Objective To investigate the efficacy of cilostazol combined with aspirin in the treatment of acute cerebral infarction and its impact on hemorheological indices.Methods A total of 96 patients with acute cerebral infarction admitted to and treated in Zhongshan Hospital,the First Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2021 to June 2022 were selected and divided into Group A(n=48)and Group B(n=48)according to the random number table method.Group A was treated with aspirin,while Group B was treated with cilostazol combined with aspirin.Both groups were treated for 2 weeks.The neurological function,hemorheological indices,levels of inflammatory factors(IL-6,TNF-α),clinical efficacy,adverse reactions(ADRs)and prognosis of the two groups were compared.Results After treatment,the scores of National Institutes of Health Stroke Scale(NIHSS)all decreased in both groups,with statistically significant difference(P<0.05).After treatment,the NIHSS score of Group B was lower than that of Group A,with statistically significant difference(P<0.05).After treatment,the high-shear whole blood viscosity,low-shear whole blood viscosity,plasma viscosity and fibrinogen in the two groups all decreased,with statistically significant differences(P<0.05).After treatment,the high-shear whole blood viscosity,low-shear whole blood viscosity,plasma viscosity and fibrinogen in Group B were lower than those in Group A,with statistically significant differences(P<0.05).After treatment,the levels of IL-6 and TNF-α in the two groups all decreased,with statistically significant differences(P<0.05).After treatment,the levels of IL-6 and TNF-α in Group B were lower than those in Group A,with statistically significant differences(P<0.05).The total rate of clinical efficacy in Group B was higher than that in Group A,with statistically significant difference(P<0.05).There was no statistically significant difference in total incidence of ADRs between Group A and Group B(P>0.05).The total incidence of adverse prognosis in Group B was lower than that in Group A,with statistically significant difference(P<0.05).Conclusion Cilostazol combined with aspirin has better efficacy in the treatment of acute cerebral infarction,which can improve neurological function and hemorheological indices,reduce the level of inflammatory factors and improve the prognosis of patients,and is worthy of promotion.关键词
西洛他唑/阿司匹林/急性脑梗死/疗效/血液流变学指标Key words
Cilostazol/Aspirin/Acute cerebral infarction/Efficacy/Hemorheological indices分类
医药卫生
