中国合理用药探索2025，Vol.22Issue(3)：55-61,7.DOI:10.3969/j.issn.2096-3327.2025.03.010
益气健心汤联合常规治疗对慢性心力衰竭患者心室重构、血管内皮功能和血清半乳糖凝集素-3、分泌型卷曲相关蛋白2水平的影响
Effects of Yiqi Jianxin Decoction Combined with Conventional Therapy on Ventricular Remodeling,Vascular Endothelial Function and Serum Levels of Galectin-3 and Secreted Frizzled-Related Protein 2 in Patients with Chronic Heart Failure
摘要
Abstract
Objective:To investigate the effects of Yiqi Jianxin decoction combined with conventional therapy on ventricular remodeling,vascular endothelial function and serum levels of Galectin-3,secreted frizzled-related protein 2(SFRP2)in patients with chronic heart failure.Methods:A total of 105 patients with chronic heart failure visited the hospital from August 2022 to May 2024 were selected and divided into the control group(n=50,after excluding 2 cases with poor treatment compliance)and the observation group(n=50,after excluding 1 case with poor treatment compliance,1 case with sudden cerebral infarction during treatment,1 case of voluntary withdrawal),using random number table method.The control group was given conventional western medicines for symptomatic treatment,and the observation group was treated with Yiqi Jianxin decoction in addition to the control treatment.The traditional Chinese medicine(TCM)symptom scores,6-minute walking distance(6MWD),Galectin-3,SFRP2,N-terminal pro-brain natriuretic peptide(NT-proBNP),vascular endothelial function[endothelin(ET),nitric oxide(NO),calcitonin gene-related peptide(CGRP)],cardiac function index[left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),stroke volume(SV),mitral flow maximum velocity/mitral flow maximum velocity during atrial systole(E/A)],clinical efficacy and adverse reactions were compared between the two groups.Results:After treatment,the TCM symptom score was decreased in both groups(P<0.05),and lower in the observation group than in the control group(P<0.05).6MWD was increased in both groups(P<0.05),and higher in the observation group than in the control group(P<0.05).The levels of Galectin-3,NT-proBNP and ET were decreased in both groups(P<0.05),and lower in the observation group than in the control group(P<0.05).The levels of SFRP2,NO and CGRP were increased in both groups(P<0.05),and higher in the observation group than in the control group(P<0.05).LVESD was decreased in both groups(P<0.05),and lower in the observation group than in the control group(P<0.05).LVEF,SV and E/A were increased in both groups(P<0.05),and higher in the observation group than in the control group(P<0.05).The total effective rate in the observation group(94.00%)was higher than that in the control group(78.00%,P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(χ2=0.000,P=1.000).Conclusion:Yiqi Jianxin decoction combined with conventional therapy has better clinical efficacy in patients with chronic heart failure,which can significantly improve ventricular remodeling and vascular endothelial function,regulate serum Galectin-3 and SFRP2 levels,without increasing the risk of adverse reactions.关键词
益气健心汤/慢性心力衰竭/心室重构/血管内皮功能/疗效Key words
Yiqi Jianxin decoction/chronic heart failure/ventricular remodeling/vascular endothelial function/efficacy分类
临床医学引用本文复制引用
付占宇,李相中,张克清..益气健心汤联合常规治疗对慢性心力衰竭患者心室重构、血管内皮功能和血清半乳糖凝集素-3、分泌型卷曲相关蛋白2水平的影响[J].中国合理用药探索,2025,22(3):55-61,7.基金项目
河南省医学科技攻关计划项目(LHGJ20220144) （LHGJ20220144）
