中兽医医药杂志2025，Vol.44Issue(2)：8-15,8.DOI:10.13823/j.cnki.jtcvm.2025.005
常山提取物联合牛至油抗鸡柔嫩艾美耳球虫作用研究
The action of Radix Dichroae extractive combined with oregano essential oil against Eimeria tenella
摘要
Abstract
The aim was to study the effect of Radix Dichroae extractive combined with oregano oil in anti-chicken coccidia.Eighty 14-day-old coccidia-free Ross 308 broilers were randomly divided into Radix Dichroae extractive combined with oregano oil group,Radix Dichroae extractive group,positive control group and blank control group.At the age of 15-24 days,broilers of two administration groups received drugs.At the age of 16 days,each chicken of two administration groups and positive control group was infected orally with 1×104 sporulated oocysts of Eimeria tenella,and the experiment ended at the age of 24 days.The results showed that bloody stool score in Radix Dichroae extractive combined with oregano oil group was significantly lower than that of positive control group(P<0.05)on the 5th to 7th day after infection,and the relative weight gain rate was significantly higher than that of positive control group(P<0.05).The cecum lesion value and oocysts value of the chickens in the administration groups were significantly lower than those of positive control group(P<0.05),and the ACI(Anticoccidial Index)was more than 166,which had a good anti-coccidial effect.On the 4th and 8th day after infection,the serum levels of proinflammatory cytokines such as IL-1β and TNF-α were significantly decreased in the administration groups compared with those in the positive control group(P<0.05).At the same time,the content of IL-10 in serum was significantly increased(P<0.05).The levels of T-AOC and SOD were significantly up-regulated,and the levels of MDA and NO were significantly down-regulated in the administration groups compared with the positive control group(P<0.05).On the 8th day after infection,there was no significant difference in the contents of CRE,UA,AST and ALT between Radix Dichroae extractive combined with origanum oil group and blank control group(P>0.05).On the 8th day after infection,the levels of CRE,UA,AST and ALT in Radix Dichroae extractive group was significantly higher than that of the blank control group(P<0.05).This study shows that in the case of good anti-coccidial effect,the combination of Radix Dichroae extractive and oregano oil can reduce the side effects of Radix Dichroae on the chicken.关键词
常山提取物/牛至油/柔嫩艾美耳球虫/鸡Key words
Radix Dichroae extractive/oregano oil/Eimeria tenella/chicken分类
农业科技引用本文复制引用
齐珍珍,苏杰,郝成宇,徐海城,王鹏,褚耀诚,马利芹,方素芳,付旭东..常山提取物联合牛至油抗鸡柔嫩艾美耳球虫作用研究[J].中兽医医药杂志,2025,44(2):8-15,8.基金项目
河北省研究生专业学位教学案例(库)建设项目(KCJSZ2024101) （库）
河北北方学院校级科研项目(XJ2024004) （XJ2024004）
河北省科技厅重点研发计划项目(19226610D) （19226610D）
