中兽医医药杂志2025，Vol.44Issue(2)：37-42,6.DOI:10.13823/j.cnki.jtcvm.2024.094
连翘脂素药理作用、制备工艺及应用研究进展
Review on pharmacology,preparation and application of phillygenin
摘要
Abstract
Phillygenin is a naturally occurring small molecule compound of the dihydrofuran class,which is the active component derived from the deglycosylation of phillyin,predominantly found in plants such as Fructus Forsythiae,Osmanthus Fragrans,Arctium lappa leaves and Radix Ranunculi Ternati.It exhibits a range of pharmacological activities,including anti-inflammatory,antioxidant,hepatoprotective,antitumor,antibacterial,antiviral,immunomodulatory,analgesic,hypotensive,and vasodilatory effects.Preparation methods for phillygenin encompass chemical extraction,microbial biotransformation,and chemical synthesis.However,the extraction and preparation of this natural product are relatively costly due to factors such as low extraction efficiency,thereby advocating for a future research trajectory that prioritizes synthetic methodologies for the generation of phillygenin.Phillygenin is characterized by low water solubility,incomplete absorption,and limited permeability,which contribute to its low oral bioavailability.To enhance its solubility and bioavailability,formulations such as phillygenin nanosuspensions,microspheres,and microemulsions have been developed.This review summarized the physicochemical properties,pharmacological effects,preparation methods,and formulation development of phillygenin,aiming to provide a reference for in-depth research,drug development,and clinical application of phillygenin.关键词
连翘/连翘脂素/药理作用/制备工艺/剂型/应用Key words
Fructus Forsythiae/phillygenin/pharmacologic action/preparation/pharmaceutical dosage forms/application分类
农业科技引用本文复制引用
孟冰冰,郭志廷,路晓荣,李建喜,张景艳,梁春花,徐国伟,毛鹏年,杨泽,李成,古雪艳,王磊,冯海鹏..连翘脂素药理作用、制备工艺及应用研究进展[J].中兽医医药杂志,2025,44(2):37-42,6.基金项目
国家重点研发计划(2023YFD1800804-02) （2023YFD1800804-02）
中国农业科学院科技创新工程(CAAS-ASTIP-2015-LIHPS) （CAAS-ASTIP-2015-LIHPS）
