中兽医医药杂志2025，Vol.44Issue(2)：43-48,封3,7.DOI:10.13823/j.cnki.jtcvm.2024.103
基于网络药理学探究增液颗粒治疗便秘的作用机制
Exploring the mechanism of Zengye granules in treating constipation based on network pharmacology
摘要
Abstract
Sow constipation is a common disease in the middle and late stages of pregnancy,and if not treated promptly,it can cause harm to both sows and piglets.Zengye granules,derived from Zengyetang,have been clinically proven effective in treating sow-related constipation symptoms such as low fever,scanty and dark urine,and defecation difficulties.Based on network pharmacology,this study explored the mechanism of action for Zengye granules in treating constipation.Active components and key targets were collected through databases such as TCMSP,selecting common targets related to constipation to construct a PPI network.The DAVID database was used to perform GO functional annotation and KEGG pathway enrichment analysis on the targets.Molecular docking verification was conducted between the predicted active ingredients and core targets.The results showed that the main active ingredients of Zengye granules were methyl ophiopogonanone A/B,ophiopogonanone A,lauric acid,etc.The core targets related to constipation mainly included SRC,AKT1,IL-6,TNF,ESR1,etc.The GO functional results showed that the main biological processes for the enrichment of fluid enhancing particles in constipation included phosphorylation,protein phosphorylation,etc.The cellular composition results showed that most of the targets were related to dendrites,neuronal cell body,neuronal projections,etc.The molecular functions were mainly enriched in protein serine/threonine/tyrosine kinase activity,protein kinase activity,protein binding,etc.The mechanism of treating constipation might be related to pathways in cancer,ErbB and PI3K/AKT signaling pathway.The molecular docking results indicated that the active ingredients of the drug had good binding affinity with the core target of the disease.The effective active ingredients in Zengye granules,such as methyl ophiopogonanone A/B,ophiopogonanone A,lauric acid,etc,could improve constipation by acting on targets like TNF,AKT,IL-6,and regulating signaling pathways such as PI3K/AKT.关键词
增液颗粒/网络药理学/便秘/信号通路/作用机制Key words
Zengye granules/network pharmacology/constipation/signal pathway/action mechanism分类
农业科技引用本文复制引用
吕凤霞,袁小兵,展光建,刘斌,李灵娟,李坤,董世山..基于网络药理学探究增液颗粒治疗便秘的作用机制[J].中兽医医药杂志,2025,44(2):43-48,封3,7.基金项目
河南省重点研发专项(221111111600) （221111111600）
