摘要
Abstract
Objective:To investigate the effects of doxofylline combined with Budesonide on symptoms and pulmonary function in patients with asthma.Method:A total of 104 asthma patients admitted to Zunyi Infectious Disease Hospital from April 2022 to April 2024 were selected as the study objects and divided into a control group and an observation group according to the random number table.The control group(52 cases)were treated with budesonide,while the observation group(52 cases)was treated with doxofylline and budesonide.The changes of small airway response,lung function,adverse reactions and clinical efficacy of the two groups were observed.Result:The maximum respiraory airflow at each level of vital capacity in the observation group were significantly higher than those in the control group,with statistical significance(P<0.05).The levels of Forced Vital Capacity(FVC),Percentage of Predicated Value of Forced Expiratory Volume in One Second(FEV1%),Percentage of Predicted Maximal Voluntary Ventilation(MVV%)and Peak Expiratory Flow(PEF)were significantly higher than those of control group,with statistical significance(P<0.05).There was no statistical significance in the occurrence of nausea and vomiting,dysphagia,abdominal pain and tachycardia between the two groups(P>0.05).And the curative effect of the observation group was significantly higher than that of the control group,with statistical significance(P<0.05).Conclusion:Doxofylline and budesonide combined therapy can relieve inflammation,improve small airway function and lung function,and reduce oxidative stress in patients with asthma.The efficacy is safe and reliable.关键词
支气管哮喘/多索茶碱/布地奈德/肺功能/症状Key words
Asthma/Doxofylline/Budesonide/Lung function/Symptoms
