Novel silver nanoparticles loaded Cu-based metal-organic framework as a promising antimicrobial material for controlling Escherichia coli O157:H7 in porkOA
The risk of infection following consumption of foodborne pathogens contaminated foods became a significant concern for human health and imposes great economic losses to food industry.Herein,Ag nanoparticles were integrated to Cu-based metal-organic framework(Cu-MOF)for antibacterial activity.The crystal structure,morphology and composition of the prepared composite Ag@Cu-MOF were confirmed by powder X-ray diffraction,thermogravimetric analysis,scanning electron microscope,transmission electron microscope,Fourier transform infrared spectroscopy,and X-ray photoelectron spectroscopy.Antibacterial assays revealed that Ag@Cu-MOF exhibited increased inhibitory activity against Escherichia coli O157:H7 in comparison to Cu-MOF.Ag@Cu-MOF treated bacterial cells displayed distinct morphological changes,a decreased ratio of live/dead cells,as well as a reduction of intracellular ATP.Antibiofilm studies demonstrated that Ag@CuMOF could dramatically inhibit biofilm formation and disrupt preformed biofilms by interfering the metabolic activity and decreasing the expression of biofilm-associated genes.Food contamination model illustrated that Ag@Cu-MOF significantly prevented the growth of E.coli O157:H7 in packed pork.This study sheds light on the potential of Ag@Cu-MOF as a promising antimicrobial material for preserving pork.
Dongbo Yang;Jing Yi;Xiaoya Li;Shuqi Zhang;Yiming Xiang;Xingxing Liu;Zhongguo Shan;Haihua Wang
College of Food Science and Engineering,Northwest A&F University,Yangling 712100,ChinaCollege of Food Science and Engineering,Northwest A&F University,Yangling 712100,ChinaCollege of Food Science and Engineering,Northwest A&F University,Yangling 712100,ChinaCollege of Food Science and Engineering,Northwest A&F University,Yangling 712100,ChinaCollege of Food Science and Engineering,Northwest A&F University,Yangling 712100,ChinaCollege of Food Science and Engineering,Northwest A&F University,Yangling 712100,ChinaCollege of Food Science and Engineering,Northwest A&F University,Yangling 712100,ChinaCollege of Food Science and Engineering,Northwest A&F University,Yangling 712100,China
轻工业
Metal-organic frameworksAntimicrobialAntibiofilmPork model
《Food Science and Human Wellness》 2025 (3)
P.914-924,11
funded by the Key Research and Development Projects of Shaanxi Province(2023-YBNY-178)Shaanxi Fundamental Science Research Project for Chemistry&Biology(22JHQ029)China Postdoctoral Science Foundation(2019M653766)National Natural Science Foundation of China(21901212)。
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