首页|期刊导航|Neural Regeneration Research|Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress

Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress

Yumei Liao Qinghua Zhang Qiaoyun Shi Peng Liu Peiyun Zhong Lingling Guo Zijian Huang Yinghui Peng Wei Liu Shiqing Zhang István Adorján Yumi Fukuzaki Eri Kawashita Xiao-Qi Zhang Nan Ma Xiaoshen Zhang Zoltán Molnár Lei Shi

Neural Regeneration Research2026，Vol.21Issue(1)：P.333-345,13.

Neural Regeneration Research2026，Vol.21Issue(1)：P.333-345,13.DOI:10.4103/NRR.NRR-D-24-00044

Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress

Yumei Liao ¹Qinghua Zhang ²Qiaoyun Shi ²Peng Liu ³Peiyun Zhong ²Lingling Guo ³Zijian Huang ³Yinghui Peng ³Wei Liu ⁴Shiqing Zhang ³István Adorján ⁵Yumi Fukuzaki ⁶Eri Kawashita ⁷Xiao-Qi Zhang ³Nan Ma ⁸Xiaoshen Zhang ⁹Zoltán Molnár ¹⁰Lei Shi¹

作者信息

1. Department of Cardiovascular Surgery,The First Affiliated Hospital,Jinan University,Guangzhou,Guangdong Province,China State Key Laboratory of Bioactive Molecules and Druggability Assessment,Jinan University,Guangzhou,Guangdong Province,China JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research,Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy,Jinan University,Guangzhou,Guangdong Province,China
2. JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research,Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy,Jinan University,Guangzhou,Guangdong Province,China
3. State Key Laboratory of Bioactive Molecules and Druggability Assessment,Jinan University,Guangzhou,Guangdong Province,China JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research,Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy,Jinan University,Guangzhou,Guangdong Province,China
4. Shenzhen Key Laboratory for Neuronal Structural Biology,Biomedical Research Institute,Institute of Geriatric Medicine,Peking University Shenzhen Hospital,Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center,Shenzhen,Guangdong Province,China
5. Department of Anatomy,Histology and Embryology,Semmelweis University,Budapest,Hungary
6. Department of Neurology,University of California,San Francisco,San Francisco,CA,USA
7. Department of Pathological Biochemistry,Kyoto Pharmaceutical University,Yamashina-ku,Kyoto,Japan
8. State Key Laboratory of Bioactive Molecules and Druggability Assessment,Jinan University,Guangzhou,Guangdong Province,China
9. Department of Cardiovascular Surgery,The First Affiliated Hospital,Jinan University,Guangzhou,Guangdong Province,China School of Nursing,Jinan University,Guangzhou,Guangdong Province,China
10. Department of Physiology,Anatomy and Genetics,University of Oxford,Oxford,UK
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摘要

关键词

endoplasmic reticulum stress/ischemia-reperfusion injury/neuron/neuronal apoptosis/neuroprotection/neuroserpin/protein synthesis/secretory protein/stroke/transcriptomic analysis

分类

医药卫生

引用本文复制引用

Yumei Liao,Qinghua Zhang,Qiaoyun Shi,Peng Liu,Peiyun Zhong,Lingling Guo,Zijian Huang,Yinghui Peng,Wei Liu,Shiqing Zhang,István Adorján,Yumi Fukuzaki,Eri Kawashita,Xiao-Qi Zhang,Nan Ma,Xiaoshen Zhang,Zoltán Molnár,Lei Shi..Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress[J].Neural Regeneration Research,2026,21(1):P.333-345,13.

基金项目

supported in part by the National Key Research&Development Program of China,No. 2022YFA1104900 (to LS) （to LS）

the National Natural Science Foundation of China,Nos. 82371175, 82071535 (both to LS), 82101614 (to YP) （both to LS）

the International Science and Technology Cooperation Projects of Guangdong Province,No. 2023A0505050121 (to LS) （to LS）

Guangdong Basic and Applied Basic Research Foundation,Nos. 2022B1515130007 (to LS), 2023A1515030012 (to SZ), 2022A1515010666 (to WL) （to LS）

the Science and Technology Program of Guangzhou,Nos. 202102070001 (to LS), 202201010041 (to YP) （to LS）

Shenzhen Basic Research Grant,Nos. JCYJ20200109140414636, JCYJ20230807145103007 (both to WL) （both to WL）

awarded a Royal Society Newton Advanced Fellowship,No. AOMS-NAF0051003 （）

in collaboration with Zoltán Molnár,Department of Physiology,Anatomy and Genetics,University of Oxford (2017–2021)。（2017–2021）

Neural Regeneration Research

ISSN：1673-5374

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