磁共振成像2025，Vol.16Issue(3)：31-37,7.DOI:10.12015/issn.1674-8034.2025.03.005
脑小血管病患者DTI-ALPS及血管周围间隙改变及其与认知功能的关联性研究
The association between DTI-ALPS,perivascular space and cognitive impairment in cerebral small vessel disease
赵婧含 1常佩佩 1杜伟 1曹家骏 1王嫚 1胡帅 1宋清伟 1苗延巍1
作者信息
- 1. 大连医科大学附属第一医院放射科,大连 116011
- 折叠
摘要
Abstract
Objective:To evaluate the glymphatic system with diffusion tensor imaging analysis along the perivascular space(DTI-ALPS)and enlarged perivascular space(EPVS)changes,and to explore its relationship with cognitive function,and then to find influence factors for cognitive changes in cerebral small vessel disease(CSVD)patients.Materials and Methods:The clinical data of CSVD group(n=81)and control group(n=20)were prospectively collected.According to the neuropsychological evaluation results,the CSVD patients were divided into normal cognition group(CSVD-NC,n=27),mild cognitive impairment group(CSVD-MCI,n=31),and vascular dementia group(CSVD-VaD,n=23).The routine MRI sequence,diffusion tensor imaging(DTI)were performed in all.The grade of EPVS of basal ganglia(BG)and centrum semi-ovale(CSO)was quantitatively scored,and ALPS-index was measured.The differences of EPVS and ALPS-index were compared among the four groups.Correlation analysis and multiple linear regression was further analyzed between ALPS-index,EPVS and cognitive function.Results:Compared with the HC group,the ALPS-index were decreased in the CSVD-NC group,CSVD-MCI group and CSVD-VaD group,the BG-EPVS and CSO-EPVS score were increased in the CSVD-MCI group and the CSVD-VaD group(P<0.05).The BG-EPVS was negatively correlated with ALPS index,MoCA score and MMSE score in CSVD patients(r=-0.291,P=0.008;r=-0.342,P=0.002;r=-0.309,P=0.005),and ALPS-index was positively correlated with MoCA score and MMSE score(r=0.226,P=0.043;r=0.225,P=0.044).Multiple linear regression analysis showed that BG-EPVS was independent factor of MoCA score and MMSE score(β=-0.294,P=0.009;β=-0.274,P=0.017).Conclusions:The ALPS index and EPVS changes could be used to evaluate glymphatic system in CSVD patients,which were closely related to cognition impairment.关键词
脑小血管疾病/沿血管周围间隙的扩散张量成像分析/磁共振成像/类淋巴系统/认知功能/血管周围间隙Key words
cerebral small vessel disease/diffusion tensor imaging analysis along the perivascular space/magnetic resonance imaging/glymphatic system/cognitive impairment/perivascular space分类
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赵婧含,常佩佩,杜伟,曹家骏,王嫚,胡帅,宋清伟,苗延巍..脑小血管病患者DTI-ALPS及血管周围间隙改变及其与认知功能的关联性研究[J].磁共振成像,2025,16(3):31-37,7.
